Transgene sequences free of CG dinucleotides lead to high level, long-term expression in the lung independent of plasmid backbone design

Transgene sequences free of CG dinucleotides lead to high level, long-term expression in the lung independent of plasmid backbone design

Non-viral aerosol gene therapy offers great potential for treating chronic lung diseases of the airways such as cystic fibrosis (CF). Early clinical trials showed that transgene expression in the airways was transient whereas maximal duration of transgene expression is essential in order to minimise...

Descripció completa

Dades bibliogràfiques
Autors principals:	Bazzani, R, Pringle, I, Connolly, M, Davies, L, Sumner-Jones, S, Schleef, M, Hyde, S, Gill, D
Format:	Journal article
Idioma:	English
Publicat:	Elsevier 2016

Ítems similars

743. Minicircles are similar to plasmids in providing high level, long-term expression in the lung
per: Gill, D, et al.
Publicat: (2016)

Influence of CpG-dinucleotide motifs on the duration of gene expression from plasmid, vectors after in vivo lung delivery
per: Gill, DR, et al.
Publicat: (2007)

CpG-free plasmid expression cassettes for cystic fibrosis gene therapy
per: Pringle, I, et al.
Publicat: (2012)

CpG-free plasmid expression cassettes for cystic fibrosis gene therapy.
per: Pringle, I, et al.
Publicat: (2012)

DEVELOPMENT, PRODUCTION AND EVALUATION OF CLINICAL GRADE CFTR EXPRESSION PLASMID FOR CF LUNG GENE THERAPY
per: Gill, DR, et al.
Publicat: (2010)

The tendency to recreate ancestral CG dinucleotides in the human genome
per: Li Mingkun, et al.
Publicat: (2011-01-01)

The use of CpG-free plasmids to mediate persistent gene expression following repeated aerosol delivery of pDNA/PEI complexes.
per: Davies, L, et al.
Publicat: (2012)

An Alternative Class of Targets for microRNAs Containing CG Dinucleotide
per: Wennan Dai, et al.
Publicat: (2022-03-01)

Strategies for long-term expression of transgenes in the respiratory epithelium.
per: Gill, DR, et al.
Publicat: (2010)

Progress and prospects: the design and production of plasmid vectors.
per: Gill, DR, et al.
Publicat: (2009)

Tracking myeloid malignancies by targeted analysis of successive DNA methylation at neighboring CG dinucleotides
per: Monika Eipel, et al.
Publicat: (2019-08-01)

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.
per: Hyde, S, et al.
Publicat: (2008)

Plasmid Inhalation: Delivery to the Airways
per: Davies, L, et al.
Publicat: (2006)

Plasmids for therapy and vaccination /
per: Schleef, M. (Martin)
Publicat: (2001)

HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP
per: Paola Miyazato, et al.
Publicat: (2019-12-01)

Elimination of the plasmid bacterial backbone in site-directed transgenesis
per: Jannik E. Jakobsen, et al.
Publicat: (2010-04-01)

The significance of plasmid DNA preparations contaminated with bacterial genomic DNA on inflammatory responses following delivery of lipoplexes to the murine lung.
per: Bazzani, R, et al.
Publicat: (2011)

Detection of plasmid DNA vectors following gene transfer to the murine airways.
per: Pringle, I, et al.
Publicat: (2005)

Generation of marker- and/or backbone-free transgenic wheat plants via Agrobacterium-mediated transformation
per: Wang Genping, et al.
Publicat: (2016-09-01)

Electroporation enhances reporter gene expression following delivery of naked plasmid DNA to the lung.
per: Pringle, I, et al.
Publicat: (2007)

Author Correction: Human SARS-CoV-2 has evolved to reduce CG dinucleotide in its open reading frames
per: Yong Wang, et al.
Publicat: (2021-06-01)

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.
per: Hyde, Stephen C., et al.
Publicat: (2008)

Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio
per: Zengzeng Lu, et al.
Publicat: (2022-12-01)

AdEasy System Made Easier by Selecting the Viral Backbone Plasmid Preceding Homologous Recombination
per: M. Zeng, et al.
Publicat: (2001-08-01)

Electrohydrodynamic comminution: a novel technique for the aerosolisation of plasmid DNA.
per: Davies, L, et al.
Publicat: (2005)

Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter.
per: Gill, DR, et al.
Publicat: (2001)

Synonymous Dinucleotide Usage: A Codon-Aware Metric for Quantifying Dinucleotide Representation in Viruses
per: Spyros Lytras, et al.
Publicat: (2020-04-01)

Truncating the C terminus of formate dehydrogenase leads to improved preference to nicotinamide cytosine dinucleotide
per: Xiaojia Guo, et al.
Publicat: (2024-11-01)

RECONsidering sensing of cyclic dinucleotides
per: Maelfait, J, et al.
Publicat: (2017)

Synthesis of Mixed Dinucleotides by Mechanochemistry
per: Faisal Hayat, et al.
Publicat: (2022-05-01)

Repertoires of the nucleosome-positioning dinucleotides.
per: Thomas Bettecken, et al.
Publicat: (2009-01-01)

Lack of repeat transduction by recombinant adeno-associated virus type 5/5 vectors in the mouse airway.
per: Sumner-Jones, S, et al.
Publicat: (2007)

Rational Development of A Polycistronic Plasmid with A CpG-Free Bacterial Backbone as A Potential Tool for Direct Reprogramming
per: Kianoush Dormiani, et al.
Publicat: (2016-10-01)

Long-term persistence of gene expression from adeno-associated virus serotype 5 in the mouse airways.
per: Sumner-Jones, S, et al.
Publicat: (2006)

Backbone-independent NMR resonance assignments of methyl probes in large proteins
per: Santrupti Nerli, et al.
Publicat: (2021-01-01)

Backbone
per: Brandon Wint
Publicat: (2022-10-01)

backbone: An R package to extract network backbones
per: Zachary P. Neal
Publicat: (2022-01-01)

backbone: An R package to extract network backbones.
per: Zachary P Neal
Publicat: (2022-01-01)

An investigation into persistent transgene expression from plasmid vectors in the lung
per: Oliveira, C
Publicat: (2016)

The development of gene therapy for diseases of the lung.
per: Gill, DR, et al.
Publicat: (2004)