HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection

Herpes simplex virus (HSV) is the main cause of viral encephalitis in the Western world, and the type I interferon (IFN) system is important for antiviral control in the brain. Here, we have compared Ifnb induction in mixed murine brain cell cultures by a panel of HSV1 mutants, each devoid of one me...

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Bibliographic Details
Main Authors:	Bodda, C, Reinert, LS, Fruhwürth, S, Richardo, T, Sun, C, Zhang, B-C, Kalamvoki, M, Pohlmann, A, Mogensen, TH, Bergström, P, Agholme, L, O'Hare, P, Sodeik, B, Gyrd-Hansen, M, Zetterberg, H, Paludan, SR
Format:	Journal article
Language:	English
Published:	Rockefeller University Press 2020
Subjects:	Innate immunity and inflammation Infectious disease and host defense

HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection

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