MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.

MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.

The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests that mechanisms interpreting 5hmC in the CNS may differ from those present in embryonic stem cells. Here, we present quantitative, genome-wide analysis of 5hmC, 5-methylcytosine (5mC), and gene expression in differ...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Mellén, M, Ayata, P, Dewell, S, Kriaucionis, S, Heintz, N
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2012

Eitemau Tebyg

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gan: Ho, K, et al.
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Genetic modifiers of MeCP2 function in Drosophila.
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DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG.
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