MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.

MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.

The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests that mechanisms interpreting 5hmC in the CNS may differ from those present in embryonic stem cells. Here, we present quantitative, genome-wide analysis of 5hmC, 5-methylcytosine (5mC), and gene expression in differ...

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Dettagli Bibliografici
Autori principali:	Mellén, M, Ayata, P, Dewell, S, Kriaucionis, S, Heintz, N
Natura:	Journal article
Lingua:	English
Pubblicazione:	2012

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