Influence of HLA-C expression level on HIV control.
A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized the differential cell surface expression levels of all common HLA-C allotypes and tes...
| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Langue: | English |
| Publié: |
American Association for the Advancement of Science
2013
|
| _version_ | 1826285228912541696 |
|---|---|
| author | Apps, R Qi, Y Carlson, J Chen, H Gao, X Thomas, R Yuki, Y Del Prete, G Goulder, P Brumme, Z Brumme, C John, M Mallal, S Nelson, G Bosch, R Heckerman, D Stein, J Soderberg, K Moody, M Denny, T Zeng, X Fang, J Moffett, A Lifson, J Goedert, J |
| author_facet | Apps, R Qi, Y Carlson, J Chen, H Gao, X Thomas, R Yuki, Y Del Prete, G Goulder, P Brumme, Z Brumme, C John, M Mallal, S Nelson, G Bosch, R Heckerman, D Stein, J Soderberg, K Moody, M Denny, T Zeng, X Fang, J Moffett, A Lifson, J Goedert, J |
| author_sort | Apps, R |
| collection | OXFORD |
| description | A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized the differential cell surface expression levels of all common HLA-C allotypes and tested directly for effects of HLA-C expression on outcomes of HIV infection in 5243 individuals. Increasing HLA-C expression was associated with protection against multiple outcomes independently of individual HLA allelic effects in both African and European Americans, regardless of their distinct HLA-C frequencies and linkage relationships with HLA-B and HLA-A. Higher HLA-C expression was correlated with increased likelihood of cytotoxic T lymphocyte responses and frequency of viral escape mutation. In contrast, high HLA-C expression had a deleterious effect in Crohn's disease, suggesting a broader influence of HLA expression levels in human disease. |
| first_indexed | 2024-03-07T01:25:43Z |
| format | Journal article |
| id | oxford-uuid:91e91a3a-bc20-4503-948e-488edc324579 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:25:43Z |
| publishDate | 2013 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:91e91a3a-bc20-4503-948e-488edc3245792022-03-26T23:21:55ZInfluence of HLA-C expression level on HIV control.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:91e91a3a-bc20-4503-948e-488edc324579EnglishSymplectic Elements at OxfordAmerican Association for the Advancement of Science2013Apps, RQi, YCarlson, JChen, HGao, XThomas, RYuki, YDel Prete, GGoulder, PBrumme, ZBrumme, CJohn, MMallal, SNelson, GBosch, RHeckerman, DStein, JSoderberg, KMoody, MDenny, TZeng, XFang, JMoffett, ALifson, JGoedert, JA variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized the differential cell surface expression levels of all common HLA-C allotypes and tested directly for effects of HLA-C expression on outcomes of HIV infection in 5243 individuals. Increasing HLA-C expression was associated with protection against multiple outcomes independently of individual HLA allelic effects in both African and European Americans, regardless of their distinct HLA-C frequencies and linkage relationships with HLA-B and HLA-A. Higher HLA-C expression was correlated with increased likelihood of cytotoxic T lymphocyte responses and frequency of viral escape mutation. In contrast, high HLA-C expression had a deleterious effect in Crohn's disease, suggesting a broader influence of HLA expression levels in human disease. |
| spellingShingle | Apps, R Qi, Y Carlson, J Chen, H Gao, X Thomas, R Yuki, Y Del Prete, G Goulder, P Brumme, Z Brumme, C John, M Mallal, S Nelson, G Bosch, R Heckerman, D Stein, J Soderberg, K Moody, M Denny, T Zeng, X Fang, J Moffett, A Lifson, J Goedert, J Influence of HLA-C expression level on HIV control. |
| title | Influence of HLA-C expression level on HIV control. |
| title_full | Influence of HLA-C expression level on HIV control. |
| title_fullStr | Influence of HLA-C expression level on HIV control. |
| title_full_unstemmed | Influence of HLA-C expression level on HIV control. |
| title_short | Influence of HLA-C expression level on HIV control. |
| title_sort | influence of hla c expression level on hiv control |
| work_keys_str_mv | AT appsr influenceofhlacexpressionlevelonhivcontrol AT qiy influenceofhlacexpressionlevelonhivcontrol AT carlsonj influenceofhlacexpressionlevelonhivcontrol AT chenh influenceofhlacexpressionlevelonhivcontrol AT gaox influenceofhlacexpressionlevelonhivcontrol AT thomasr influenceofhlacexpressionlevelonhivcontrol AT yukiy influenceofhlacexpressionlevelonhivcontrol AT delpreteg influenceofhlacexpressionlevelonhivcontrol AT goulderp influenceofhlacexpressionlevelonhivcontrol AT brummez influenceofhlacexpressionlevelonhivcontrol AT brummec influenceofhlacexpressionlevelonhivcontrol AT johnm influenceofhlacexpressionlevelonhivcontrol AT mallals influenceofhlacexpressionlevelonhivcontrol AT nelsong influenceofhlacexpressionlevelonhivcontrol AT boschr influenceofhlacexpressionlevelonhivcontrol AT heckermand influenceofhlacexpressionlevelonhivcontrol AT steinj influenceofhlacexpressionlevelonhivcontrol AT soderbergk influenceofhlacexpressionlevelonhivcontrol AT moodym influenceofhlacexpressionlevelonhivcontrol AT dennyt influenceofhlacexpressionlevelonhivcontrol AT zengx influenceofhlacexpressionlevelonhivcontrol AT fangj influenceofhlacexpressionlevelonhivcontrol AT moffetta influenceofhlacexpressionlevelonhivcontrol AT lifsonj influenceofhlacexpressionlevelonhivcontrol AT goedertj influenceofhlacexpressionlevelonhivcontrol |