Learning patterns of HIV-1 resistance to broadly neutralizing antibodies with reduced subtype bias using multi-task learning

Learning patterns of HIV-1 resistance to broadly neutralizing antibodies with reduced subtype bias using multi-task learning

The ability to predict HIV-1 resistance to broadly neutralizing antibodies (bnAbs) will increase bnAb therapeutic benefits. Machine learning is a powerful approach for such prediction. One challenge is that some HIV-1 subtypes in currently available training datasets are underrepresented, which like...

Bibliografske podrobnosti
Main Authors:	Igiraneza, AB, Zacharopoulou, P, Hinch, R, Wymant, C, Abeler-Dörner, L, Frater, J, Fraser, C
Format:	Journal article
Jezik:	English
Izdano:	Public Library of Science 2024

Podobne knjige/članki

Learning patterns of HIV-1 resistance to broadly neutralizing antibodies with reduced subtype bias using multi-task learning.
od: Aime Bienfait Igiraneza, et al.
Izdano: (2024-11-01)

The potential of broadly neutralizing antibodies for HIV prevention
od: Huub C. Gelderblom, et al.
Izdano: (2024-05-01)

Application of the SLAPNAP statistical learning tool to broadly neutralizing antibody HIV prevention research
od: Brian D. Williamson, et al.
Izdano: (2023-09-01)

Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections.
od: Kshitij Wagh, et al.
Izdano: (2018-03-01)

Estimating SARS-CoV-2 variant fitness and the impact of interventions in England using statistical and geo-spatial agent-based models
od: Hinch, R, et al.
Izdano: (2022)

Enhancing broadly neutralising antibody suppression of HIV by immune modulation and vaccination
od: Nel, C, et al.
Izdano: (2024)

The expanding array of HIV broadly neutralizing antibodies
od: Laura E. McCoy
Izdano: (2018-10-01)

Enhancing broadly neutralising antibody suppression of HIV by immune modulation and vaccination
od: Carla Nel, et al.
Izdano: (2024-11-01)

Epidemiological changes on the Isle of Wight after the launch of the NHS Test and Trace programme: a preliminary analysis
od: Kendall, M, et al.
Izdano: (2020)

Development of broadly neutralizing antibodies in HIV-1 infected elite neutralizers
od: Elise Landais, et al.
Izdano: (2018-09-01)

Neutralizing the threat: harnessing broadly neutralizing antibodies against HIV-1 for treatment and prevention
od: Juan C Becerra, et al.
Izdano: (2024-07-01)

Optimizing immunization protocols to elicit broadly neutralizing antibodies
od: Sprenger, Kayla G, et al.
Izdano: (2021)

Contribution of rare mutational outcomes to broadly neutralizing antibodies
od: Feng Anqi, et al.
Izdano: (2022-06-01)

Cross-reactive broadly neutralizing antibodies: timing is everything
od: Zelda eEuler, et al.
Izdano: (2012-07-01)

Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies
od: Karplus, Martin, et al.
Izdano: (2018)

Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies
od: Victor Ovchinnikov, et al.
Izdano: (2018-02-01)

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies.
od: Laura E McCoy, et al.
Izdano: (2015-08-01)

Refocusing the Antibody Response: The Use of an Antibody-Masking Technique to Elicit Broadly Neutralizing Antibodies
od: Wan, D, et al.
Izdano: (2011)

Optimizing clinical dosing of combination broadly neutralizing antibodies for HIV prevention.
od: Bryan T Mayer, et al.
Izdano: (2022-04-01)

Virus Evolution and Neutralization Sensitivity in an HIV-1 Subtype B′ Infected Plasma Donor with Broadly Neutralizing Activity
od: Yuanyuan Hu, et al.
Izdano: (2021-03-01)

Exploration of broadly neutralizing antibody fragments produced in bacteria for the control of HIV
od: Sarah B. Lloyd, et al.
Izdano: (2017-11-01)

Convergent antibody responses are associated with broad neutralization of hepatitis C virus
od: Nicole E. Skinner, et al.
Izdano: (2023-03-01)

Predicting neutralization susceptibility to combination HIV-1 monoclonal broadly neutralizing antibody regimens.
od: Brian D Williamson, et al.
Izdano: (2024-01-01)

Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
od: Haynes, BF, et al.
Izdano: (2022)

Decoding broadly neutralizing antibodies: a milestone in SFTSV therapy
od: Xiaoyu Zhao, et al.
Izdano: (2025-01-01)

Broadly neutralizing antibodies for HIV-1: efficacies, challenges and opportunities
od: Yubin Liu, et al.
Izdano: (2020-01-01)

Broadly Neutralizing Antibodies for Influenza: Passive Immunotherapy and Intranasal Vaccination
od: Mrityunjoy Biswas, et al.
Izdano: (2020-07-01)

Viral Vectors for the Induction of Broadly Neutralizing Antibodies against HIV
od: Sarah Wilmschen, et al.
Izdano: (2019-09-01)

HIV-1 cell-to-cell transmission and broadly neutralizing antibodies
od: Jérémy Dufloo, et al.
Izdano: (2018-07-01)

Elimination of HIV-1-infected cells by broadly neutralizing antibodies
od: Timothée Bruel, et al.
Izdano: (2016-03-01)

Deep learning guided optimization of human antibody against SARS-CoV-2 variants with broad neutralization
od: Shan, Sisi, et al.
Izdano: (2022)

Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes
od: Yulu Chen, et al.
Izdano: (2022-12-01)

The mature EV71 virion induced a broadly cross-neutralizing VP1 antibody against subtypes of the EV71 virus.
od: Chia-Ying Wu, et al.
Izdano: (2019-01-01)

Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing
od: Ferretti, L, et al.
Izdano: (2020)

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
od: Pejchal, R, et al.
Izdano: (2011)

Computational Prediction of Broadly Neutralizing HIV-1 Antibody Epitopes from Neutralization Activity Data
od: Ferguson, Andrew L., et al.
Izdano: (2014)

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
od: Sok, Devin, et al.
Izdano: (2014)

Computational prediction of broadly neutralizing HIV-1 antibody epitopes from neutralization activity data.
od: Andrew L Ferguson, et al.
Izdano: (2013-01-01)

P04-55 LB. Anti-V3 monoclonal antibodies display broad neutralizing activities against multiple HIV-1 subtypes
od: Yu X, et al.
Izdano: (2009-10-01)

A broadly neutralizing monoclonal antibody induces broad protection against heterogeneous PRRSV strains in piglets
od: Zhigang Zhang, et al.
Izdano: (2021-03-01)