The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy.

The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy.

Spinal muscular atrophy (SMA), which is caused by inactivating mutations in the survival motor neuron 1 (SMN1) gene, is characterized by loss of lower motor neurons in the spinal cord. The gene encoding SMN is very highly conserved in evolution, allowing the disease to be modeled in a range of speci...

書目詳細資料
Main Authors:	Sleigh, J, Gillingwater, T, Talbot, K
格式:	Journal article
語言:	English
出版:	2011

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