The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy.

The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy.

Spinal muscular atrophy (SMA), which is caused by inactivating mutations in the survival motor neuron 1 (SMN1) gene, is characterized by loss of lower motor neurons in the spinal cord. The gene encoding SMN is very highly conserved in evolution, allowing the disease to be modeled in a range of speci...

书目详细资料
Main Authors:	Sleigh, J, Gillingwater, T, Talbot, K
格式:	Journal article
语言:	English
出版:	2011

相似书籍

The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy
由: James N. Sleigh, et al.
出版: (2011-07-01)

Spinal muscular atrophy at the crossroads of basic science and therapy
由: Sleigh, J, et al.
出版: (2013)

Spinal muscular atrophy at the crossroads of basic science and therapy.
由: Sleigh, J, et al.
出版: (2013)

Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy.
由: Murray, L, et al.
出版: (2010)

SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy.
由: Wishart, T, et al.
出版: (2010)

Spinal muscular atrophy.
由: Talbot, K, et al.
出版: (2001)

Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.
由: Bäumer, D, et al.
出版: (2009)

Development and Translation of Therapies for Spinal Muscular Atrophy
由: Hannah K. Shorrock, et al.
出版: (2016-07-01)

Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy.
由: Murray, L, et al.
出版: (2008)

Review: neuromuscular synaptic vulnerability in motor neurone disease: amyotrophic lateral sclerosis and spinal muscular atrophy.
由: Murray, L, et al.
出版: (2010)

Therapeutic strategies for spinal muscular atrophy: SMN and beyond
由: Bowerman, M, et al.
出版: (2017)

Therapeutic strategies for spinal muscular atrophy: SMN and beyond
由: Bowerman, M, et al.
出版: (2017)

Chapter 16 Spinal Muscular Atrophy
由: Talbot, K, et al.
出版: (2003)

Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.
由: Dirk Bäumer, et al.
出版: (2009-12-01)

Reversible molecular pathology of skeletal muscle in spinal muscular atrophy.
由: Mutsaers, C, et al.
出版: (2011)

Therapeutic strategies for spinal muscular atrophy: SMN and beyond
由: Melissa Bowerman, et al.
出版: (2017-08-01)

Invertebrate models of spinal muscular atrophy: insights into mechanisms and potential therapeutics.
由: Grice, S, et al.
出版: (2011)

Invertebrate models of spinal muscular atrophy: Insights into mechanisms and potential therapeutics
由: Grice, S, et al.
出版: (2011)

TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy
由: Turner, B, et al.
出版: (2008)

Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy.
由: Sleigh, J, et al.
出版: (2014)

TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy
由: Ansorge Olaf, et al.
出版: (2008-10-01)

Model systems for exploring new therapeutic interventions and disease mechanisms in spinal muscular atrophies (SMAs)
由: Sleigh, JN
出版: (2012)

Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy.
由: Penelope J Boyd, et al.
出版: (2017-04-01)

Molecular Pathogenesis and New Therapeutic Dimensions for Spinal Muscular Atrophy
由: Andrés López-Cortés, et al.
出版: (2022-06-01)

Chapter 7 Spinal muscular atrophies and hereditary motor neuropathies.
由: Talbot, K, et al.
出版: (2007)

Spinal Muscular Atrophy
由: J Gordon Millichap
出版: (1990-02-01)

Synaptic defects in the spinal and neuromuscular circuitry in a mouse model of spinal muscular atrophy.
由: Karen K Y Ling, et al.
出版: (2010-11-01)

Spinal muscular atrophy
由: D'Amico Adele, et al.
出版: (2011-11-01)

The altered expression of neurofilament in mouse models and patients with spinal muscular atrophy
由: Charlotte Spicer, et al.
出版: (2021-04-01)

Morphological characteristics of motor neurons do not determine their relative susceptibility to degeneration in a mouse model of severe spinal muscular atrophy.
由: Sophie R Thomson, et al.
出版: (2012-01-01)

Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy
由: Hammond, S, et al.
出版: (2016)

Modeling spinal muscular atrophy in Drosophila.
由: Chang, H, et al.
出版: (2008)

Modeling spinal muscular atrophy in Drosophila.
由: Howard Chia-Hao Chang, et al.
出版: (2008-09-01)

Spinal Muscular Atrophy and Arthrogryposis
由: J Gordon Millichap
出版: (1997-10-01)

Spinal muscular atrophies reveal motor neuron vulnerability to defects in ribonucleoprotein handling.
由: Anderson, K, et al.
出版: (2003)

MOLECULAR ANALYSIS OF CHILDHOOD-ONSET SPINAL MUSCULAR-ATROPHY
由: Theodosiou, A, et al.
出版: (1995)

Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy
由: Christian M. Simon, et al.
出版: (2019-12-01)

Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis
由: Andrew P. Tosolini, et al.
出版: (2017-12-01)

R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy
由: Rocio Tejero, et al.
出版: (2020-02-01)

Recovery of function in a myogenic mouse model of spinal bulbar muscular atrophy
由: Jamie A. Johansen, et al.
出版: (2009-04-01)