Glucose analogue inhibitors of glycogen phosphorylase: the design of potential drugs for diabetes.
The T-state crystal structure of the glucose-phosphorylase b complex has been used as a model for the design of glucose analogue inhibitors that may be effective in the regulation of blood glucose levels. Modeling studies indicated room for additional atoms attached at the C1-beta position of glucos...
Κύριοι συγγραφείς: | Martin, J, Veluraja, K, Ross, K, Johnson, L, Fleet, G, Ramsden, N, Bruce, I, Orchard, MG, Oikonomakos, N, Papageorgiou, A |
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Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
1991
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Παρόμοια τεκμήρια
Παρόμοια τεκμήρια
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The design of potential antidiabetic drugs: experimental investigation of a number of beta-D-glucose analogue inhibitors of glycogen phosphorylase.
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Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection.
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Glucopyranose spirohydantoins: Specific inhibitors of glycogen phosphorylase
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Έκδοση: (1997)