Glucose analogue inhibitors of glycogen phosphorylase: the design of potential drugs for diabetes.

Glucose analogue inhibitors of glycogen phosphorylase: the design of potential drugs for diabetes.

The T-state crystal structure of the glucose-phosphorylase b complex has been used as a model for the design of glucose analogue inhibitors that may be effective in the regulation of blood glucose levels. Modeling studies indicated room for additional atoms attached at the C1-beta position of glucos...

Bibliografiset tiedot
Päätekijät:	Martin, J, Veluraja, K, Ross, K, Johnson, L, Fleet, G, Ramsden, N, Bruce, I, Orchard, MG, Oikonomakos, N, Papageorgiou, A
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	1991

Samankaltaisia teoksia

GLUCOSE ANALOG INHIBITORS OF GLYCOGEN-PHOSPHORYLASE
Tekijä: Johnson, L, et al.
Julkaistu: (1994)

INHIBITORS OF GLYCOGEN-PHOSPHORYLASE
Tekijä: Bichard, C, et al.
Julkaistu: (1994)

The design of potential antidiabetic drugs: experimental investigation of a number of beta-D-glucose analogue inhibitors of glycogen phosphorylase.
Tekijä: Oikonomakos, N, et al.
Julkaistu: (1994)

Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection.
Tekijä: Watson, K, et al.
Julkaistu: (1995)

Glucopyranose spirohydantoins: Specific inhibitors of glycogen phosphorylase
Tekijä: delaFuente, C, et al.
Julkaistu: (1997)

Design of inhibitors of glycogen phosphorylase: a study of alpha- and beta-C-glucosides and 1-thio-beta-D-glucose compounds.
Tekijä: Watson, K, et al.
Julkaistu: (1994)

Stereospecific synthesis of spirohydantoins of beta-glucopyranose: Inhibitors of glycogen phosphorylase
Tekijä: Krulle, T, et al.
Julkaistu: (1997)

Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase.
Tekijä: Watson, K, et al.
Julkaistu: (2005)

N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose.
Tekijä: Oikonomakos, N, et al.
Julkaistu: (1995)

Effects of C-1-substituted glucose analogue on the activation states of glycogen synthase and glycogen phosphorylase in rat hepatocytes.
Tekijä: Board, M, et al.
Julkaistu: (1995)

Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure.
Tekijä: Tsitsanou, K, et al.
Julkaistu: (1999)

The binding of beta-glycerophosphate to glycogen phosphorylase b in the crystal.
Tekijä: Oikonomakos, N, et al.
Julkaistu: (1989)

SPECIFIC-INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIRODIKETOPIPERAZINE AT THE ANOMERIC POSITION OF GLUCOPYRANOSE
Tekijä: Krulle, T, et al.
Julkaistu: (1995)

Phosphate-recognition sites in catalysis and control of glycogen phosphorylase b.
Tekijä: Johnson, L, et al.
Julkaistu: (1987)

POTENT INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE - FIRST PYRANOSE ANALOGS OF HYDANTOCIDIN
Tekijä: Bichard, C, et al.
Julkaistu: (1995)

Uridine(5')diphospho(1)-alpha-D-glucose. A binding study to glycogen phosphorylase b in the crystal.
Tekijä: Oikonomakos, N, et al.
Julkaistu: (1988)

Catalysis in the crystal: synchrotron radiation studies with glycogen phosphorylase b.
Tekijä: Hajdu, J, et al.
Julkaistu: (1987)

The structure of phosphorylase kinase holoenzyme at 9.9 angstroms resolution and location of the catalytic subunit and the substrate glycogen phosphorylase.
Tekijä: Vénien-Bryan, C, et al.
Julkaistu: (2009)

Pyridoxal phosphate site in glycogen phosphorylase b: structure in native enzyme and in three derivatives with modified cofactors.
Tekijä: Oikonomakos, N, et al.
Julkaistu: (1987)

Towards time-resolved diffraction studies with glycogen phosphorylase.
Tekijä: Duke, E, et al.
Julkaistu: (1991)

TOWARDS TIME-RESOLVED DIFFRACTION STUDIES WITH GLYCOGEN-PHOSPHORYLASE
Tekijä: Duke, E, et al.
Julkaistu: (1991)

TOWARDS TIME-RESOLVED DIFFRACTION STUDIES WITH GLYCOGEN-PHOSPHORYLASE
Tekijä: Duke, E, et al.
Julkaistu: (1991)

Triazole carboxylic acids as anionic sugar mimics? Inhibition of glycogen phosphorylase by a D-glucotriazole carboxylate
Tekijä: Krulle, T, et al.
Julkaistu: (1997)

Structural changes in glycogen phosphorylase induced by phosphorylation.
Tekijä: Sprang, SR, et al.
Julkaistu: (1988)

Substrate-cofactor interactions for glycogen phosphorylase b: a binding study in the crystal with heptenitol and heptulose 2-phosphate.
Tekijä: McLaughlin, P, et al.
Julkaistu: (1984)

The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 A resolution and 100 K: the role of the water structure and its contribution to binding.
Tekijä: Gregoriou, M, et al.
Julkaistu: (1998)

Studies on the glycogen phosphorylase system
Tekijä: Busby, S
Julkaistu: (1975)

Three-dimensional structure of phosphorylase kinase at 22 A resolution and its complex with glycogen phosphorylase b.
Tekijä: Vénien-Bryan, C, et al.
Julkaistu: (2002)

Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells.
Tekijä: Favaro, E, et al.
Julkaistu: (2012)

Comparison of AMP and NADH binding to glycogen phosphorylase b.
Tekijä: Stura, E, et al.
Julkaistu: (1983)

Cryocrystallographic and mechanistic studies on glycogen phosphorylase
Tekijä: Mitchell, E
Julkaistu: (1994)

C-(β-D-Glucopyranosyl) heterocycles as potential glycogen phosphorylase inhibitors
Tekijä: Zsuzsa Hadady, et al.
Julkaistu: (2004-03-01)

The role of glycogen phosphorylase in glycogen biogenesis in skeletal muscle after exercise
Tekijä: Abram Katz
Julkaistu: (2023-03-01)

Allosteric interactions of glycogen phosphorylase b. A crystallographic study of glucose 6-phosphate and inorganic phosphate binding to di-imidate-cross-linked phosphorylase b.
Tekijä: Lorek, A, et al.
Julkaistu: (1984)

On the promise of glycogen phosphorylase inhibition in acute inflammation
Tekijä: Aarooran Sivakumaran Durairaj, et al.
Julkaistu: (2021-03-01)

Transcriptional regulation of rat brain glycogen phosphorylase
Tekijä: Hamprecht Bernd, et al.
Julkaistu: (2007-03-01)

GLYCOGEN PHOSPHORYLASE-B - THE MOLECULAR ANATOMY OF A LARGE REGULATORY ENZYME
Tekijä: Sansom, M, et al.
Julkaistu: (1985)

Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases.
Tekijä: Clinch, K, et al.
Julkaistu: (2006)

Time-resolved structural studies on catalysis in the crystal with glycogen phosphorylase b.
Tekijä: Hajdu, J, et al.
Julkaistu: (1986)

Mitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity
Tekijä: Ikko Sakamoto, et al.
Julkaistu: (2024-11-01)