Childhood bone mineral content is associated with methylation status of the RXRA promoter at birth.

Maternal vitamin D deficiency has been associated with reduced offspring bone mineral accrual. Retinoid-X receptor-alpha (RXRA) is an essential cofactor in the action of 1,25-dihydroxyvitamin D (1,25[OH]2 -vitamin D), and RXRA methylation in umbilical cord DNA has been associated with later offsprin...

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Bibliographic Details
Main Authors: Harvey, N, Sheppard, A, Godfrey, K, McLean, C, Garratt, E, Ntani, G, Davies, L, Murray, R, Inskip, H, Gluckman, P, Hanson, M, Lillycrop, K, Cooper, C
Format: Conference item
Published: 2014