Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38.

The stability of cyclooxygenase 2 (Cox-2) mRNA is regulated positively by proinflammatory stimuli acting through mitogen-activated protein kinase (MAPK) p38 and negatively by anti-inflammatory glucocorticoids such as dexamethasone. A tetracycline-regulated reporter system was used to investigate mec...

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Bibliografiske detaljer
Main Authors: Lasa, M, Brook, M, Saklatvala, J, Clark, A
Format: Journal article
Sprog:English
Udgivet: 2001