Work-up and management of paediatric Cushing's syndrome.
PURPOSE OF REVIEW: Paediatric Cushing's syndrome presents a diagnostic and therapeutic challenge. Most paediatric endocrinologists have limited experience in managing children or adolescents with Cushing's syndrome and thus benefit from close consultation with adult colleagues. A protocol...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797082310300925952 |
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| author | Savage, M Chan, L Grossman, AB Storr, H |
| author_facet | Savage, M Chan, L Grossman, AB Storr, H |
| author_sort | Savage, M |
| collection | OXFORD |
| description | PURPOSE OF REVIEW: Paediatric Cushing's syndrome presents a diagnostic and therapeutic challenge. Most paediatric endocrinologists have limited experience in managing children or adolescents with Cushing's syndrome and thus benefit from close consultation with adult colleagues. A protocol for investigation of the child with suspected Cushing's syndrome is presented followed by principles of management. RECENT FINDINGS: Cushing's syndrome is rare in childhood, but causes serious morbidity. Investigations have evolved and now include new genetic and imaging techniques as well as classical endocrine studies. In Cushing's disease trans-sphenoidal surgery has transformed management, although only a few surgeons have experience in children. Pituitary radiotherapy is effective second-line therapy. SUMMARY: Early diagnosis and treatment of Cushing's syndrome is vital for long-term outcome. The overall prognosis for Cushing's syndrome is good but challenges remain to ensure normal postcure growth and body composition. |
| first_indexed | 2024-03-07T01:26:20Z |
| format | Journal article |
| id | oxford-uuid:921b5cb7-d8c2-40a2-8555-790f02fa93c2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:26:20Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:921b5cb7-d8c2-40a2-8555-790f02fa93c22022-03-26T23:23:11ZWork-up and management of paediatric Cushing's syndrome.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:921b5cb7-d8c2-40a2-8555-790f02fa93c2EnglishSymplectic Elements at Oxford2008Savage, MChan, LGrossman, ABStorr, H PURPOSE OF REVIEW: Paediatric Cushing's syndrome presents a diagnostic and therapeutic challenge. Most paediatric endocrinologists have limited experience in managing children or adolescents with Cushing's syndrome and thus benefit from close consultation with adult colleagues. A protocol for investigation of the child with suspected Cushing's syndrome is presented followed by principles of management. RECENT FINDINGS: Cushing's syndrome is rare in childhood, but causes serious morbidity. Investigations have evolved and now include new genetic and imaging techniques as well as classical endocrine studies. In Cushing's disease trans-sphenoidal surgery has transformed management, although only a few surgeons have experience in children. Pituitary radiotherapy is effective second-line therapy. SUMMARY: Early diagnosis and treatment of Cushing's syndrome is vital for long-term outcome. The overall prognosis for Cushing's syndrome is good but challenges remain to ensure normal postcure growth and body composition. |
| spellingShingle | Savage, M Chan, L Grossman, AB Storr, H Work-up and management of paediatric Cushing's syndrome. |
| title | Work-up and management of paediatric Cushing's syndrome. |
| title_full | Work-up and management of paediatric Cushing's syndrome. |
| title_fullStr | Work-up and management of paediatric Cushing's syndrome. |
| title_full_unstemmed | Work-up and management of paediatric Cushing's syndrome. |
| title_short | Work-up and management of paediatric Cushing's syndrome. |
| title_sort | work up and management of paediatric cushing s syndrome |
| work_keys_str_mv | AT savagem workupandmanagementofpaediatriccushingssyndrome AT chanl workupandmanagementofpaediatriccushingssyndrome AT grossmanab workupandmanagementofpaediatriccushingssyndrome AT storrh workupandmanagementofpaediatriccushingssyndrome |