Integrating mass spectrometry with MD simulations reveals the role of lipids in Na(+)/H(+) antiporters

Na(+)/H(+) antiporters are found in all kingdoms of life and exhibit catalysis rates that are among the fastest of all known secondary-active transporters. Here we combine ion mobility mass spectrometry and molecular dynamics simulations to study the conformational stability and lipid-binding proper...

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Bibliographic Details
Main Authors: Landreh, M, Marklund, E, Uzdavinys, P, Degiacomi, M, Coincon, M, Gault, J, Gupta, K, Liko, I, Benesch, J, Drew, D, Robinson, C
Format: Journal article
Language:English
Published: Springer Nature 2017