Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation.
Integrins are large membrane-spanning receptors fundamental to cell adhesion and migration. Integrin adhesiveness for the extracellular matrix is activated by the cytoskeletal protein talin via direct binding of its phosphotyrosine-binding-like F3 domain to the cytoplasmic tail of the beta integrin...
Main Authors: | Anthis, N, Haling, JR, Oxley, C, Memo, M, Wegener, K, Lim, C, Ginsberg, M, Campbell, I |
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Format: | Journal article |
Language: | English |
Published: |
2009
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