Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma.
E-cadherin is crucial to the intercellular adherens junctions which are involved in the organisation and maintenance of epithelial structure and suppression of tumour invasion. E-cadherin is associated with the actin cytoskeleton via cytoplasmic proteins, including alpha-, beta- and gamma-catenins,...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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| _version_ | 1797082410939056128 |
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| author | Hao, X Palazzo, J Ilyas, M Tomlinson, I Talbot, I |
| author_facet | Hao, X Palazzo, J Ilyas, M Tomlinson, I Talbot, I |
| author_sort | Hao, X |
| collection | OXFORD |
| description | E-cadherin is crucial to the intercellular adherens junctions which are involved in the organisation and maintenance of epithelial structure and suppression of tumour invasion. E-cadherin is associated with the actin cytoskeleton via cytoplasmic proteins, including alpha-, beta- and gamma-catenins, which together form the cadherin/catenin complex. To evaluate changes of the molecules of the cadherin/catenin complex in colorectal carcinogenesis, seventy-four sporadic adenomas, samples of histologically normal epithelium adjacent to 65 adenomas, and 52 carcinomas arising in adenomas were investigated by immunohistochemistry. All normal epithelial cells showed a uniform membranous staining pattern for E-cadherin, alpha-, beta-, and gamma-catenin. Decreased expression of all 4 proteins occurred in parallel in adenomas and carcinomas (in all cases, p < 10(-5). Decreased expression of the cadherin/catenin complex in adenomas was associated with increasing severity of dysplasia (p < 0.001, for E-cadherin, alpha-, and gamma-catenin, p < 0.005 for beta-catenin). Carcinomas displayed significantly reduced expression of the cadherin/catenin complex compared with their associated adenomas (all p < 0.001). The results directly confirm that colorectal tumour progression and invasion is associated with disruption of the cadherin/catenin complex and suggest that the genetic changes and transcriptional modulation of catenins underlying this progression may affect all members of the complex. |
| first_indexed | 2024-03-07T01:27:47Z |
| format | Journal article |
| id | oxford-uuid:928bf34c-af88-42bc-8168-d8de6bd31e23 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:27:47Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:928bf34c-af88-42bc-8168-d8de6bd31e232022-03-26T23:26:21ZReduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:928bf34c-af88-42bc-8168-d8de6bd31e23EnglishSymplectic Elements at Oxford1997Hao, XPalazzo, JIlyas, MTomlinson, ITalbot, IE-cadherin is crucial to the intercellular adherens junctions which are involved in the organisation and maintenance of epithelial structure and suppression of tumour invasion. E-cadherin is associated with the actin cytoskeleton via cytoplasmic proteins, including alpha-, beta- and gamma-catenins, which together form the cadherin/catenin complex. To evaluate changes of the molecules of the cadherin/catenin complex in colorectal carcinogenesis, seventy-four sporadic adenomas, samples of histologically normal epithelium adjacent to 65 adenomas, and 52 carcinomas arising in adenomas were investigated by immunohistochemistry. All normal epithelial cells showed a uniform membranous staining pattern for E-cadherin, alpha-, beta-, and gamma-catenin. Decreased expression of all 4 proteins occurred in parallel in adenomas and carcinomas (in all cases, p < 10(-5). Decreased expression of the cadherin/catenin complex in adenomas was associated with increasing severity of dysplasia (p < 0.001, for E-cadherin, alpha-, and gamma-catenin, p < 0.005 for beta-catenin). Carcinomas displayed significantly reduced expression of the cadherin/catenin complex compared with their associated adenomas (all p < 0.001). The results directly confirm that colorectal tumour progression and invasion is associated with disruption of the cadherin/catenin complex and suggest that the genetic changes and transcriptional modulation of catenins underlying this progression may affect all members of the complex. |
| spellingShingle | Hao, X Palazzo, J Ilyas, M Tomlinson, I Talbot, I Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma. |
| title | Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma. |
| title_full | Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma. |
| title_fullStr | Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma. |
| title_full_unstemmed | Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma. |
| title_short | Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma. |
| title_sort | reduced expression of molecules of the cadherin catenin complex in the transition from colorectal adenoma to carcinoma |
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