MHC II molecules in inflammatory diseases: interplay of qualities and quantities.
It is generally accepted that MHC II molecules confer susceptibility to inflammatory diseases because of the different abilities they possess for binding and presenting peptides to T cells. A new study suggests that the level of MHC II gene expression is also a risk factor for such diseases. It show...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2005
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| _version_ | 1797082442918526976 |
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| author | Friese, M Jones, E Fugger, L |
| author_facet | Friese, M Jones, E Fugger, L |
| author_sort | Friese, M |
| collection | OXFORD |
| description | It is generally accepted that MHC II molecules confer susceptibility to inflammatory diseases because of the different abilities they possess for binding and presenting peptides to T cells. A new study suggests that the level of MHC II gene expression is also a risk factor for such diseases. It shows that a polymorphism in the promoter of the MHC II transactivator (MHC2TA) gene (which encodes CIITA), leads to reduced MHC2TA expression, and hence reduced production of MHC II molecules. This predisposes to rheumatoid arthritis, multiple sclerosis and myocardial infarction. |
| first_indexed | 2024-03-07T01:28:10Z |
| format | Journal article |
| id | oxford-uuid:92ae3241-abf2-41f5-a2d5-5da24a34eb6a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:28:10Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:92ae3241-abf2-41f5-a2d5-5da24a34eb6a2022-03-26T23:27:15ZMHC II molecules in inflammatory diseases: interplay of qualities and quantities.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:92ae3241-abf2-41f5-a2d5-5da24a34eb6aEnglishSymplectic Elements at Oxford2005Friese, MJones, EFugger, LIt is generally accepted that MHC II molecules confer susceptibility to inflammatory diseases because of the different abilities they possess for binding and presenting peptides to T cells. A new study suggests that the level of MHC II gene expression is also a risk factor for such diseases. It shows that a polymorphism in the promoter of the MHC II transactivator (MHC2TA) gene (which encodes CIITA), leads to reduced MHC2TA expression, and hence reduced production of MHC II molecules. This predisposes to rheumatoid arthritis, multiple sclerosis and myocardial infarction. |
| spellingShingle | Friese, M Jones, E Fugger, L MHC II molecules in inflammatory diseases: interplay of qualities and quantities. |
| title | MHC II molecules in inflammatory diseases: interplay of qualities and quantities. |
| title_full | MHC II molecules in inflammatory diseases: interplay of qualities and quantities. |
| title_fullStr | MHC II molecules in inflammatory diseases: interplay of qualities and quantities. |
| title_full_unstemmed | MHC II molecules in inflammatory diseases: interplay of qualities and quantities. |
| title_short | MHC II molecules in inflammatory diseases: interplay of qualities and quantities. |
| title_sort | mhc ii molecules in inflammatory diseases interplay of qualities and quantities |
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