Improved immunohistochemical detection of type 1 insulin-Like growth factor receptor in human tumors

Improved immunohistochemical detection of type 1 insulin-Like growth factor receptor in human tumors

<p><strong>Background:</strong> Insulin-like growth factors (IGFs) are known to play important roles in cancer biology, prompting evaluation of drugs targeting type 1 IGF receptor (IGF-1R). However, there is considerable lack of consensus in immunohistochemical (IHC) studies of IGF...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Macaulay, V, Aleksic, T, Turley, H, Worrall, A, Verrill, C, Campo, L
Formatua:	Journal article
Argitaratua:	OMICS International Journals 2016

Antzeko izenburuak

Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells.
nork: Aleksic, T, et al.
Argitaratua: (2010)

The type 1 insulin-like growth factor receptor pathway.
nork: Chitnis, M, et al.
Argitaratua: (2008)

Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer.
nork: Yuen, J, et al.
Argitaratua: (2008)

Targeting the type 1 insulin-like growth factor receptor as anti-cancer treatment.
nork: Bohula, E, et al.
Argitaratua: (2003)

Insulin like growth factor receptor 1 (IGF-1R) and radiotherapy resistance in laryngeal squamous cell cancer (LSCC)
nork: Qureishi, A, et al.
Argitaratua: (2018)

The type 1 insulin-like growth factor receptor is over-expressed in bladder cancer.
nork: Rochester, M, et al.
Argitaratua: (2007)

Chemosensitization of human prostate cancer using antisense agents targeting the type 1 insulin-like growth factor receptor.
nork: Hellawell, G, et al.
Argitaratua: (2003)

Validation of the type 1 insulin-like growth factor receptor as a therapeutic target in renal cancer.
nork: Yuen, J, et al.
Argitaratua: (2009)

Validation of the type 1 insulin-like growth factor receptor as a therapeutic target in renal cancer
nork: Yuen, J, et al.
Argitaratua: (2009)

Silencing of the insulin receptor isoform A favors formation of type 1 insulin-like growth factor receptor (IGF-IR) homodimers and enhances ligand-induced IGF-IR activation and viability of human colon carcinoma cells.
nork: Brierley, G, et al.
Argitaratua: (2010)

Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease.
nork: Hellawell, G, et al.
Argitaratua: (2002)

Activation of the insulin receptor by insulin-like growth factor 2
nork: Weidong An, et al.
Argitaratua: (2024-03-01)

Immunohistochemical detection of angiotensin receptors AT1 and AT2 in adrenal tumors.
nork: Marek Pawlikowski, et al.
Argitaratua: (2008-02-01)

Immunohistochemical detection of FSH receptors in pituitary adenomas and adrenal tumors
nork: Marek Pawlikowski, et al.
Argitaratua: (2012-10-01)

Phase I study of OSI-906, dual tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) in combination with erlotinib (E) in patients with advanced solid tumors.
nork: Macaulay, V, et al.
Argitaratua: (2010)

Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase.
nork: Macaulay, V, et al.
Argitaratua: (2001)

The insulin-like growth factor system as a therapeutic target in colorectal cancer.
nork: Hassan, A, et al.
Argitaratua: (2002)

How ligand binds to the type 1 insulin-like growth factor receptor
nork: Yibin Xu, et al.
Argitaratua: (2018-02-01)

Type 1 insulin-like growth factor receptor inhibition as treatment for urological cancer
nork: Chitnis, M, et al.
Argitaratua: (2013)

Role of the Insulin-Like Growth Factor Type 1 Receptor in the Pathogenesis of Diabetic Encephalopathy
nork: Duo Zhang, et al.
Argitaratua: (2015-01-01)

Ligand-mediated Endocytosis and Trafficking of the Insulin-like Growth Factor Receptor I and Insulin Receptor Modulate Receptor Function
nork: Alaide eMorcavallo, et al.
Argitaratua: (2014-12-01)

The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript.
nork: Bohula, E, et al.
Argitaratua: (2003)

Insulin-Like Growth Factor Binding Protein-6 Promotes the Differentiation of Placental Mesenchymal Stem Cells into Skeletal Muscle Independent of Insulin-Like Growth Factor Receptor-1 and Insulin Receptor
nork: Doaa Aboalola, et al.
Argitaratua: (2019-01-01)

Expression and cellular localization of vascular endothelial growth factor A and its receptors in acute and chronic leukemias: an immunohistochemical study.
nork: Zhang, Y, et al.
Argitaratua: (2005)

Bad to the bone: The role of the insulin-like growth factor axis in osseous metastasis
nork: Rieunier, G, et al.
Argitaratua: (2019)

Lectin-induced alterations of the interaction of insulin and insulin-like growth factor 1 receptors with their ligands
nork: ROMANA MASNIKOSA, et al.
Argitaratua: (2008-08-01)

Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II.
nork: Clair L Alvino, et al.
Argitaratua: (2011-01-01)

Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin.
nork: Playford, M, et al.
Argitaratua: (2000)

Immunohistochemical expression of estrogen receptors, progesterone receptors, and human epidermal growth-factor receptor 2/neu in epithelial ovarian tumors
nork: Zaineb Y Mohieldin, et al.
Argitaratua: (2022-01-01)

Genetic variation in the type 2 insulin-like growth factor receptor gene and disparity in childhood height.
nork: Petry, C, et al.
Argitaratua: (2005)

Extended silencing of the insulin-like growth factor-I receptor gene in MCF-7 cells by serial transfection with siRNA.
nork: McVittie, C, et al.
Argitaratua: (2006)

Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.
nork: Dora Maria Cedano Prieto, et al.
Argitaratua: (2017-01-01)

Immunohistochemical expression of Insulin-like growth factor-1, Transforming growth factor-beta1, and Vascular endothelial growth factor in parathyroid adenoma and hyperplasia
nork: Hamide Sayar, et al.
Argitaratua: (2014-01-01)

Insulin-like growth factor ligands, receptors, and binding proteins in cancer.
nork: Foulstone, E, et al.
Argitaratua: (2005)

Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection
nork: Ammaji Rajala, et al.
Argitaratua: (2022-07-01)

Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes
nork: Kim Moorwood, et al.
Argitaratua: (2024-05-01)

Reduced expression of the growth hormone and type 1 insulin-like growth factor receptors in human somatotroph tumours and an analysis of possible mutations of the growth hormone receptor.
nork: Kola, B, et al.
Argitaratua: (2003)

miR-140 inhibits porcine fetal fibroblasts proliferation by directly targeting type 1 insulin-like growth factor receptor and indirectly inhibiting type 1 insulin-like growth factor receptor expression via SRY-box 4
nork: Hongwei Geng, et al.
Argitaratua: (2020-10-01)

Somatostatin receptors in human adrenal gland tumors--immunohistochemical study.
nork: Tomasz Stepień, et al.
Argitaratua: (2008-12-01)

Phase I study of humanized monoclonal antibody AVE1642 directed against the type 1 insulin-like growth factor receptor (IGF-1R), administered in combination with anticancer therapies to patients with advanced solid tumors.
nork: Macaulay, V, et al.
Argitaratua: (2013)