Memory recall involves a transient break in excitatory-inhibitory balance
The brain has a remarkable capacity to acquire and store memories that can later be selectively recalled. These processes are supported by the hippocampus which is thought to index memory recall by reinstating information stored across distributed neocortical circuits. However, the mechanism that su...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
eLife Sciences Publications
2021
|
| _version_ | 1826285407468257280 |
|---|---|
| author | Koolschijn, RS Shpektor, A Clarke, WT Ip, IB Dupret, D Emir, UE Barron, HC |
| author_facet | Koolschijn, RS Shpektor, A Clarke, WT Ip, IB Dupret, D Emir, UE Barron, HC |
| author_sort | Koolschijn, RS |
| collection | OXFORD |
| description | The brain has a remarkable capacity to acquire and store memories that can later be selectively recalled. These processes are supported by the hippocampus which is thought to index memory recall by reinstating information stored across distributed neocortical circuits. However, the mechanism that supports this interaction remains unclear. Here, in humans, we show that recall of a visual cue from a paired associate is accompanied by a transient increase in the ratio between glutamate and GABA in visual cortex. Moreover, these excitatory-inhibitory fluctuations are predicted by activity in the hippocampus. These data suggest the hippocampus gates memory recall by indexing information stored across neocortical circuits using a disinhibitory mechanism. |
| first_indexed | 2024-03-07T01:28:22Z |
| format | Journal article |
| id | oxford-uuid:92bc1214-d0ba-4249-a812-b4cb3c5da201 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:28:22Z |
| publishDate | 2021 |
| publisher | eLife Sciences Publications |
| record_format | dspace |
| spelling | oxford-uuid:92bc1214-d0ba-4249-a812-b4cb3c5da2012022-03-26T23:27:40ZMemory recall involves a transient break in excitatory-inhibitory balanceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:92bc1214-d0ba-4249-a812-b4cb3c5da201EnglishSymplectic ElementseLife Sciences Publications2021Koolschijn, RSShpektor, AClarke, WTIp, IBDupret, DEmir, UEBarron, HCThe brain has a remarkable capacity to acquire and store memories that can later be selectively recalled. These processes are supported by the hippocampus which is thought to index memory recall by reinstating information stored across distributed neocortical circuits. However, the mechanism that supports this interaction remains unclear. Here, in humans, we show that recall of a visual cue from a paired associate is accompanied by a transient increase in the ratio between glutamate and GABA in visual cortex. Moreover, these excitatory-inhibitory fluctuations are predicted by activity in the hippocampus. These data suggest the hippocampus gates memory recall by indexing information stored across neocortical circuits using a disinhibitory mechanism. |
| spellingShingle | Koolschijn, RS Shpektor, A Clarke, WT Ip, IB Dupret, D Emir, UE Barron, HC Memory recall involves a transient break in excitatory-inhibitory balance |
| title | Memory recall involves a transient break in excitatory-inhibitory balance |
| title_full | Memory recall involves a transient break in excitatory-inhibitory balance |
| title_fullStr | Memory recall involves a transient break in excitatory-inhibitory balance |
| title_full_unstemmed | Memory recall involves a transient break in excitatory-inhibitory balance |
| title_short | Memory recall involves a transient break in excitatory-inhibitory balance |
| title_sort | memory recall involves a transient break in excitatory inhibitory balance |
| work_keys_str_mv | AT koolschijnrs memoryrecallinvolvesatransientbreakinexcitatoryinhibitorybalance AT shpektora memoryrecallinvolvesatransientbreakinexcitatoryinhibitorybalance AT clarkewt memoryrecallinvolvesatransientbreakinexcitatoryinhibitorybalance AT ipib memoryrecallinvolvesatransientbreakinexcitatoryinhibitorybalance AT dupretd memoryrecallinvolvesatransientbreakinexcitatoryinhibitorybalance AT emirue memoryrecallinvolvesatransientbreakinexcitatoryinhibitorybalance AT barronhc memoryrecallinvolvesatransientbreakinexcitatoryinhibitorybalance |