Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity.
The role of processing in antigen (Ag) presentation and T cell activation in experimental allergic encephalomyelitis (EAE) was evaluated in wild-type mice, mice that selectively express either Ii p31 or p41, and mice completely deficient in Ii or H-2M. We demonstrate that processing of myelin oligod...
Váldodahkkit: | Slavin, A, Soos, J, Stuve, O, Patarroyo, J, Weiner, H, Fontana, A, Bikoff, E, Zamvil, S |
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Materiálatiipa: | Journal article |
Giella: | English |
Almmustuhtton: |
2001
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Geahča maid
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Requirement for antigen processing and influence of invariant chain and H-2M deficiencies on T-Cell activation in autoimmune encephalomyelitis
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Influence of invariant chain and H-2M deficiencies in antigen processing and T cell activation in autoimmune encephalomyelitis.
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Astrocytes express elements of the class II endocytic pathway and process central nervous system autoantigen for presentation to encephalitogenic T cells.
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