Oxygen free radical scavenger enzyme polymorphisms in systemic sclerosis.
We performed a case-control study of polymorphisms of glutathione S-transferase (GST) isoenzymes and manganese superoxide dismutase (MnSOD) in black South Africans with systemic sclerosis (SSc). The frequency of the GSTM1*B phenotype was significantly decreased in the overall SSc group compared with...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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| _version_ | 1797082466514632704 |
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| author | Tikly, M Marshall, SE Haldar, N Gulumian, M Wordsworth, P Welsh, K |
| author_facet | Tikly, M Marshall, SE Haldar, N Gulumian, M Wordsworth, P Welsh, K |
| author_sort | Tikly, M |
| collection | OXFORD |
| description | We performed a case-control study of polymorphisms of glutathione S-transferase (GST) isoenzymes and manganese superoxide dismutase (MnSOD) in black South Africans with systemic sclerosis (SSc). The frequency of the GSTM1*B phenotype was significantly decreased in the overall SSc group compared with controls (OR=0.19, p(corr)<.05), implying a possible protective effect against development of the disease. There was also a trend toward increased MnSODAla allele and phenotype frequencies in the diffuse cutaneous SSc subset compared with controls (OR=2.11 and 3.15, respectively, p(corr)<.1). Our findings provide new data on the distribution of GST and MnSOD polymorphisms in healthy Africans and further evidence that genetic factors may have a contributory role to play in predisposing to oxidative stress in SSc. |
| first_indexed | 2024-03-07T01:28:31Z |
| format | Journal article |
| id | oxford-uuid:92c9e577-b690-4d85-a14d-24ebdd6f6a32 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:28:31Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:92c9e577-b690-4d85-a14d-24ebdd6f6a322022-03-26T23:28:00ZOxygen free radical scavenger enzyme polymorphisms in systemic sclerosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:92c9e577-b690-4d85-a14d-24ebdd6f6a32EnglishSymplectic Elements at Oxford2004Tikly, MMarshall, SEHaldar, NGulumian, MWordsworth, PWelsh, KWe performed a case-control study of polymorphisms of glutathione S-transferase (GST) isoenzymes and manganese superoxide dismutase (MnSOD) in black South Africans with systemic sclerosis (SSc). The frequency of the GSTM1*B phenotype was significantly decreased in the overall SSc group compared with controls (OR=0.19, p(corr)<.05), implying a possible protective effect against development of the disease. There was also a trend toward increased MnSODAla allele and phenotype frequencies in the diffuse cutaneous SSc subset compared with controls (OR=2.11 and 3.15, respectively, p(corr)<.1). Our findings provide new data on the distribution of GST and MnSOD polymorphisms in healthy Africans and further evidence that genetic factors may have a contributory role to play in predisposing to oxidative stress in SSc. |
| spellingShingle | Tikly, M Marshall, SE Haldar, N Gulumian, M Wordsworth, P Welsh, K Oxygen free radical scavenger enzyme polymorphisms in systemic sclerosis. |
| title | Oxygen free radical scavenger enzyme polymorphisms in systemic sclerosis. |
| title_full | Oxygen free radical scavenger enzyme polymorphisms in systemic sclerosis. |
| title_fullStr | Oxygen free radical scavenger enzyme polymorphisms in systemic sclerosis. |
| title_full_unstemmed | Oxygen free radical scavenger enzyme polymorphisms in systemic sclerosis. |
| title_short | Oxygen free radical scavenger enzyme polymorphisms in systemic sclerosis. |
| title_sort | oxygen free radical scavenger enzyme polymorphisms in systemic sclerosis |
| work_keys_str_mv | AT tiklym oxygenfreeradicalscavengerenzymepolymorphismsinsystemicsclerosis AT marshallse oxygenfreeradicalscavengerenzymepolymorphismsinsystemicsclerosis AT haldarn oxygenfreeradicalscavengerenzymepolymorphismsinsystemicsclerosis AT gulumianm oxygenfreeradicalscavengerenzymepolymorphismsinsystemicsclerosis AT wordsworthp oxygenfreeradicalscavengerenzymepolymorphismsinsystemicsclerosis AT welshk oxygenfreeradicalscavengerenzymepolymorphismsinsystemicsclerosis |