CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef.

CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef.

CTL play a critical role in the control of HIV and SIV. However, intrinsic genetic instability enables these immunodeficiency viruses to evade detection by CTL through mutation of targeted antigenic sites. These mutations can impair binding of viral epitopes to the presenting MHC class I molecule or...

Bibliografiset tiedot
Päätekijät:	Milicic, A, Price, D, Zimbwa, P, Booth, B, Brown, H, Easterbrook, P, Olsen, K, Robinson, N, Gileadi, U, Sewell, A, Cerundolo, V, Phillips, R
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	2005

Samankaltaisia teoksia

Role of the proteasome and non proteasomal proteases in the generation of CTL epitopes.
Tekijä: Cerundolo, V, et al.
Julkaistu: (1998)

Effect of epitope flanking residues on the presentation of N-terminal cytotoxic T lymphocyte epitopes.
Tekijä: Gileadi, U, et al.
Julkaistu: (1999)

Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein.
Tekijä: Gileadi, U, et al.
Julkaistu: (1999)

Effects of retroviral protease inhibitors on proteasome function and processing of HIV-derived MHC class I-restricted cytotoxic T lymphocyte epitopes.
Tekijä: Kelleher, A, et al.
Julkaistu: (2001)

Differential processing of HLA A2-restricted HIV type 1 cytotoxic T lymphocyte epitopes.
Tekijä: Sewell, A, et al.
Julkaistu: (2002)

IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase.
Tekijä: Sewell, A, et al.
Julkaistu: (1999)

CD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope.
Tekijä: Chihiro Motozono, et al.
Julkaistu: (2013-01-01)

Identification of a novel HLA-A24-restricted cytotoxic T-lymphocyte epitope within HIV-1 Nef.
Tekijä: Goulder, P, et al.
Julkaistu: (1997)

HIV-1 down-regulates the expression of CD1d via Nef.
Tekijä: Chen, N, et al.
Julkaistu: (2006)

Identification of a novel HLA-B*2705-restricted cytotoxic T-lymphocyte epitope within a conserved region of HIV-1 Nef.
Tekijä: Goulder, P, et al.
Julkaistu: (1997)

The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells.
Tekijä: Cerundolo, V, et al.
Julkaistu: (1997)

Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes
Tekijä: Ebstein, F, et al.
Julkaistu: (2016)

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue.
Tekijä: Dorota Kmiec, et al.
Julkaistu: (2018-08-01)

Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes.
Tekijä: Oxenius, A, et al.
Julkaistu: (2000)

Modulation of proteasomal activity required for the generation of a cytotoxic T lymphocyte-defined peptide derived from the tumor antigen MAGE-3.
Tekijä: Valmori, D, et al.
Julkaistu: (1999)

CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope.
Tekijä: Sylvain Cardinaud, et al.
Julkaistu: (2011-05-01)

AP-2 Adaptor Complex-Dependent Enhancement of HIV-1 Replication by Nef in the Absence of the Nef/AP-2 Targets SERINC5 and CD4
Tekijä: Balaji Olety, et al.
Julkaistu: (2023-02-01)

Increased synapse formation obtained by T cell epitopes containing a CxxC motif in flanking residues convert CD4+ T cells into cytolytic effectors.
Tekijä: Vincent A Carlier, et al.
Julkaistu: (2012-01-01)

Embryonic alcohol exposure disrupts the ubiquitin-proteasome system
Tekijä: Olivia Weeks, et al.
Julkaistu: (2022-12-01)

Cross-staining of cytotoxic T lymphocyte populations with peptide-MHC class I multimers of natural HIV-1 variant antigens.
Tekijä: Oxenius, A, et al.
Julkaistu: (2001)

Kelam’da Nefs Fenomenolojisi
Tekijä: Tuğba Günal
Julkaistu: (2022-06-01)

HIV-1 Nef: at the crossroads
Tekijä: Garcia J Victor, et al.
Julkaistu: (2008-09-01)

Nef and HIV/SIV Replication
Tekijä: Peterlin Matija
Julkaistu: (2005-12-01)

A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities.
Tekijä: Marta Martínez-Bonet, et al.
Julkaistu: (2015-01-01)

An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses.
Tekijä: André, P, et al.
Julkaistu: (1998)

Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes.
Tekijä: Mann, J, et al.
Julkaistu: (2013)

The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells
Tekijä: Emily N. Pawlak, et al.
Julkaistu: (2018-01-01)

Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages
Tekijä: Suzu Shinya, et al.
Julkaistu: (2011-06-01)

How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4
Tekijä: Xuefeng Ren, et al.
Julkaistu: (2014-01-01)

Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection.
Tekijä: Julianne V de Carvalho, et al.
Julkaistu: (2014-01-01)

Human T-cell leukemia virus type 1 Tax protein binds to assembled nuclear proteasomes and enhances their proteolytic activity.
Tekijä: Hemelaar, J, et al.
Julkaistu: (2001)

Disruption of the Ubiquitin-Proteasome System and Elevated Endoplasmic Reticulum Stress in Epilepsy
Tekijä: Sarah Poliquin, et al.
Julkaistu: (2022-03-01)

Proteasome dysfunction disrupts adipogenesis and induces inflammation via ATF3
Tekijä: Nienke Willemsen, et al.
Julkaistu: (2022-08-01)

Ölümünün 350. yılında Nef'i
Tekijä: Tulga Ocak
Julkaistu: (1985-12-01)

The Nef activity on HIV-1 infectivity
Tekijä: Stéphane eBasmaciogullari, et al.
Julkaistu: (2014-05-01)

Self-association of the Lentivirus protein, Nef
Tekijä: Garcia J Victor, et al.
Julkaistu: (2010-09-01)

Alâaddîn el-Kirmânî’de İbn Sînâcı Nefs Anlayışının Ekberî Dönüşümü: Özgün Bir Nefs Teorisi
Tekijä: Enes Taş
Julkaistu: (2024-09-01)

Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection.
Tekijä: Michael Schindler, et al.
Julkaistu: (2008-07-01)

Epitopes of the CD4 antigen and HIV infection.
Tekijä: Sattentau, Q, et al.
Julkaistu: (1986)

Antigen processing defects in cervical carcinomas limit the presentation of a CTL epitope from human papillomavirus 16 E6.
Tekijä: Evans, M, et al.
Julkaistu: (2001)