The RNA-dependent RNA polymerase of the influenza A virus
The influenza A virus causes a highly contagious respiratory disease that significantly impacts our economy and health. Its replication and transcription is catalyzed by the viral RNA polymerase. This enzyme is also crucial for the virus, because it is involved in the adaptation of zoonotic strains....
| Main Authors: | , |
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| Format: | Journal article |
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Future Medicine
2014
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| _version_ | 1797082514938920960 |
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| author | Stubbs, T te Velthuis, A |
| author_facet | Stubbs, T te Velthuis, A |
| author_sort | Stubbs, T |
| collection | OXFORD |
| description | The influenza A virus causes a highly contagious respiratory disease that significantly impacts our economy and health. Its replication and transcription is catalyzed by the viral RNA polymerase. This enzyme is also crucial for the virus, because it is involved in the adaptation of zoonotic strains. It is thus of major interest for the development of antiviral therapies and is being intensively studied. In this article, we will discuss recent advances that have improved our knowledge of the structure of the RNA polymerase and how mutations in the polymerase help the virus to spread effectively among new hosts. |
| first_indexed | 2024-03-07T01:29:00Z |
| format | Journal article |
| id | oxford-uuid:92f3ce97-d7c8-4d06-a65d-3ca5de48056e |
| institution | University of Oxford |
| last_indexed | 2024-03-07T01:29:00Z |
| publishDate | 2014 |
| publisher | Future Medicine |
| record_format | dspace |
| spelling | oxford-uuid:92f3ce97-d7c8-4d06-a65d-3ca5de48056e2022-03-26T23:29:02ZThe RNA-dependent RNA polymerase of the influenza A virusJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:92f3ce97-d7c8-4d06-a65d-3ca5de48056eSymplectic Elements at OxfordFuture Medicine2014Stubbs, Tte Velthuis, AThe influenza A virus causes a highly contagious respiratory disease that significantly impacts our economy and health. Its replication and transcription is catalyzed by the viral RNA polymerase. This enzyme is also crucial for the virus, because it is involved in the adaptation of zoonotic strains. It is thus of major interest for the development of antiviral therapies and is being intensively studied. In this article, we will discuss recent advances that have improved our knowledge of the structure of the RNA polymerase and how mutations in the polymerase help the virus to spread effectively among new hosts. |
| spellingShingle | Stubbs, T te Velthuis, A The RNA-dependent RNA polymerase of the influenza A virus |
| title | The RNA-dependent RNA polymerase of the influenza A virus |
| title_full | The RNA-dependent RNA polymerase of the influenza A virus |
| title_fullStr | The RNA-dependent RNA polymerase of the influenza A virus |
| title_full_unstemmed | The RNA-dependent RNA polymerase of the influenza A virus |
| title_short | The RNA-dependent RNA polymerase of the influenza A virus |
| title_sort | rna dependent rna polymerase of the influenza a virus |
| work_keys_str_mv | AT stubbst thernadependentrnapolymeraseoftheinfluenzaavirus AT tevelthuisa thernadependentrnapolymeraseoftheinfluenzaavirus AT stubbst rnadependentrnapolymeraseoftheinfluenzaavirus AT tevelthuisa rnadependentrnapolymeraseoftheinfluenzaavirus |