Alpha 2-adrenoceptor agonists stimulate growth hormone secretion but have no acute effects on plasma cortisol under basal conditions.
Ten normal male subjects were administered clonidine (0.1 and 0.2 mg) or a highly-selective alpha 2-adrenoceptor agonist S 3341 (1 and 2 mg) on separate occasions in a double-blind randomised placebo-controlled study; blood samples were obtained for measurement of serum GH and plasma cortisol via an...
| Hlavní autoři: | , , , , |
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| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
1987
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| _version_ | 1826285451860770816 |
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| author | Grossman, A Weerasuriya, K Al-Damluji, S Turner, P Besser, G |
| author_facet | Grossman, A Weerasuriya, K Al-Damluji, S Turner, P Besser, G |
| author_sort | Grossman, A |
| collection | OXFORD |
| description | Ten normal male subjects were administered clonidine (0.1 and 0.2 mg) or a highly-selective alpha 2-adrenoceptor agonist S 3341 (1 and 2 mg) on separate occasions in a double-blind randomised placebo-controlled study; blood samples were obtained for measurement of serum GH and plasma cortisol via an indwelling venous cannula for 4 h after each drug administration. Both clonidine and S 3341 were equally effective at lowering supine, and particularly standing BP; both also caused mild sedation, although this was slightly less marked for S 3341. High doses of both clonidine and S 3341 significantly increased serum GH (peak increment after clonidine: 18.8 +/- 5.5 mU/l (mean +/- SEM); peak increment after S 3341: 21.1 +/- 4.8 mU/l). Neither drug affected plasma cortisol. It is concluded that GH release may be stimulated by alpha 2-adrenoceptor agonism. As S 3341 has slightly less central activity than clonidine at the doses employed, but is at least equally potent at stimulating GH release, it is probable that the alpha 2-adrenoceptor stimulation of GH release occurs outside the blood-brain barrier. The pituitary-adrenal axis appears resistant to manipulation of alpha 2-adrenoceptors under basal conditions. |
| first_indexed | 2024-03-07T01:29:03Z |
| format | Journal article |
| id | oxford-uuid:92f96393-cde4-43b9-b256-295d9b7a6e34 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:29:03Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:92f96393-cde4-43b9-b256-295d9b7a6e342022-03-26T23:29:09ZAlpha 2-adrenoceptor agonists stimulate growth hormone secretion but have no acute effects on plasma cortisol under basal conditions.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:92f96393-cde4-43b9-b256-295d9b7a6e34EnglishSymplectic Elements at Oxford1987Grossman, AWeerasuriya, KAl-Damluji, STurner, PBesser, GTen normal male subjects were administered clonidine (0.1 and 0.2 mg) or a highly-selective alpha 2-adrenoceptor agonist S 3341 (1 and 2 mg) on separate occasions in a double-blind randomised placebo-controlled study; blood samples were obtained for measurement of serum GH and plasma cortisol via an indwelling venous cannula for 4 h after each drug administration. Both clonidine and S 3341 were equally effective at lowering supine, and particularly standing BP; both also caused mild sedation, although this was slightly less marked for S 3341. High doses of both clonidine and S 3341 significantly increased serum GH (peak increment after clonidine: 18.8 +/- 5.5 mU/l (mean +/- SEM); peak increment after S 3341: 21.1 +/- 4.8 mU/l). Neither drug affected plasma cortisol. It is concluded that GH release may be stimulated by alpha 2-adrenoceptor agonism. As S 3341 has slightly less central activity than clonidine at the doses employed, but is at least equally potent at stimulating GH release, it is probable that the alpha 2-adrenoceptor stimulation of GH release occurs outside the blood-brain barrier. The pituitary-adrenal axis appears resistant to manipulation of alpha 2-adrenoceptors under basal conditions. |
| spellingShingle | Grossman, A Weerasuriya, K Al-Damluji, S Turner, P Besser, G Alpha 2-adrenoceptor agonists stimulate growth hormone secretion but have no acute effects on plasma cortisol under basal conditions. |
| title | Alpha 2-adrenoceptor agonists stimulate growth hormone secretion but have no acute effects on plasma cortisol under basal conditions. |
| title_full | Alpha 2-adrenoceptor agonists stimulate growth hormone secretion but have no acute effects on plasma cortisol under basal conditions. |
| title_fullStr | Alpha 2-adrenoceptor agonists stimulate growth hormone secretion but have no acute effects on plasma cortisol under basal conditions. |
| title_full_unstemmed | Alpha 2-adrenoceptor agonists stimulate growth hormone secretion but have no acute effects on plasma cortisol under basal conditions. |
| title_short | Alpha 2-adrenoceptor agonists stimulate growth hormone secretion but have no acute effects on plasma cortisol under basal conditions. |
| title_sort | alpha 2 adrenoceptor agonists stimulate growth hormone secretion but have no acute effects on plasma cortisol under basal conditions |
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