Traficet-EN (CCX282-B), an orally active inhibitor of chemokine receptor CCR9, for treatment of Crohn's disease

Traficet-EN (CCX282-B), an orally active inhibitor of chemokine receptor CCR9, for treatment of Crohn's disease

Manylion Llyfryddiaeth
Prif Awduron:	Bekker, P, Velde, A, Pronk, I, Keshav, S, Hommes, D, Hanauer, S, Ungashe, S, Zheng, W, Wright, K, Schall, T
Fformat:	Conference item
Cyhoeddwyd:	2007

Eitemau Tebyg

PROTECT-1 Maintenance Phase Study Results demonstrate efficacy of the Intestine-Specific Chemokine Receptor Antagonist CCX282-B (Traficet-EN) in Crohn's Disease
gan: Bekker, P, et al.
Cyhoeddwyd: (2009)

Ccx282-B, an orally active inhibitor of chemokine receptor Ccr9, shows anti-inflammatory and clinical activity in the treatment of Crohn's disease
gan: Keshav, S, et al.
Cyhoeddwyd: (2007)

PROTECT-1 Study Demonstrated Efficacy of the Intestine-Specific Chemokine Receptor Antagonist CCX282-B (Traficet-EN) in Treatment of Patients with Moderate to Severe Crohn's Disease
gan: Keshav, S, et al.
Cyhoeddwyd: (2009)

Protect-1, a prospective randomized oral therapy evaluation of CCX282-B (Traficet-EN) in Crohn's disease trial
gan: Bekker, P, et al.
Cyhoeddwyd: (2008)

PROTECT-1: A prospective randomized trial of CCX282-B (Traficet-EN), a novel oral therapy targeting chemokine receptor 9 in Crohn's disease
gan: Keshav, S, et al.
Cyhoeddwyd: (2007)

Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease.
gan: Walters, M, et al.
Cyhoeddwyd: (2010)

Traficet-EN, an Oral CCR9-Specific Antagonist, induces high levels of remission in the open-label Phase of PROTECT-1 in Crohn's Disease
gan: Bekker, P, et al.
Cyhoeddwyd: (2008)

Traficet-EN, an oral CCR9-specific antagonist, induces high levels of remission in the open-label phase of PROTECT-1 in Crohn's disease
gan: Bekker, P, et al.
Cyhoeddwyd: (2008)

MEDI 167-Discovery of the highly potent, selective and orally bioavailable CCR9 antagonist CCX282-B
gan: Ungashe, S, et al.
Cyhoeddwyd: (2008)

Pharmacological inhibition of CCR9 is a novel approach in the treatment of inflammatory bowel disease
gan: Bekker, P, et al.
Cyhoeddwyd: (2007)

Cc chemokine receptor 9 (ccr9) antagonist ameliorates experimental ileitis and colitis
gan: Wei, Z, et al.
Cyhoeddwyd: (2005)

Expression and function of the chemokine receptor CCR7 in thyroid carcinomas.
gan: Sancho, M, et al.
Cyhoeddwyd: (2006)

Chemokines and myeloid cell recruitment.
gan: Greaves, D, et al.
Cyhoeddwyd: (2000)

The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus-encoded chemokine MC148, inhibits the CCR10 receptor.
gan: Lüttichau, H, et al.
Cyhoeddwyd: (2001)

Abduction of chemokine elements by herpesviruses
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Cyhoeddwyd: (1998)

CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells.
gan: Greaves, D, et al.
Cyhoeddwyd: (1997)

Variants of the chemokine receptor CCR5 are associated with severe bronchiolitis caused by respiratory syncytial virus.
gan: Hull, J, et al.
Cyhoeddwyd: (2003)

Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype
gan: Adams, P, et al.
Cyhoeddwyd: (2018)

High-Level Production, Solubilization and Purification of Synthetic Human GPCR Chemokine Receptors CCR5, CCR3, CXCR4 and CX3CR1
gan: Xu, Zhinan, et al.
Cyhoeddwyd: (2010)

TH17 T CELLS IN ANKYLOSING SPONDYLITIS ARE POLYFUNCTIONAL AND EXPRESS HIGH LEVELS OF THE CHEMOKINE RECEPTOR CCR6
gan: Bowness, P, et al.
Cyhoeddwyd: (2009)

Chemokine receptor CCR5 polymorphisms do not affect disease progression in hepatitis C virus infection.
gan: Hellier, S, et al.
Cyhoeddwyd: (2000)

CCR9 antagonism: potential in the treatment of Inflammatory Bowel Disease.
gan: Wendt, E, et al.
Cyhoeddwyd: (2015)

Highly Potent, Orally Available Anti-inflammatory Broad-Spectrum Chemokine Inhibitors
gan: Fox, D, et al.
Cyhoeddwyd: (2009)

Activation of CCR2+ human proinflammatory monocytes by human herpesvirus-6B chemokine N-terminal peptide.
gan: Clark, D, et al.
Cyhoeddwyd: (2013)

Copy number variation of c-c chemokine ligand 3-like 1 (CCL3L1), c-c chemokine receptor type 5 (CCR5) and CCR2 polymorphisms on the outcomes of antiretroviral therapy among Malaysian HIV patients
gan: Mohamad Isa, Irma Izani
Cyhoeddwyd: (2020)

Medical management of Crohn's disease.
gan: Cummings, JR, et al.
Cyhoeddwyd: (2008)

A novel membrane based process to isolate recombinant human chemokine receptor CCR3 produced in Escherichia coli
gan: Liu, J, et al.
Cyhoeddwyd: (2013)

Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection.
gan: Hellier, S, et al.
Cyhoeddwyd: (2003)

Mat 282- Pengiraan Kejuruteraan I
gan: PPSM, Pusat Pengajian Sains Matematik
Cyhoeddwyd: (2004)

Chemokines, chemokine receptors and atherosclerosis
gan: John, A, et al.
Cyhoeddwyd: (2005)

The duffy antigen/receptor for chemokines exists in an oligomeric form in living cells and functionally antagonizes CCR5 signaling through hetero-oligomerization.
gan: Chakera, A, et al.
Cyhoeddwyd: (2008)

Analysis of the CC chemokine receptor 5 (CCR5)Delta 32 polymorphism in Behcet's disease (vol 31, pg 11, 2004)
gan: Yang, X, et al.
Cyhoeddwyd: (2005)

MAT 282 - Pengiraan Kejuruteraan I - Oktober 2004
gan: PPSM, Pusat Pengajian Sains Matematik
Cyhoeddwyd: (2004)

ZAE282-3 - MATERIAL SCIENCES - NOVEMBER 2008.
gan: PPSF, Pusat Pengajian Sains Fizik
Cyhoeddwyd: (2008)

ZAE 282/3 - SAINS BAHAN SEPT 1997.
gan: PPSF, Pusat Pengajian Sains Fizik
Cyhoeddwyd: (1997)

Crohn’s disease or Crohn’s diseases?
gan: Arnott, IDR, et al.
Cyhoeddwyd: (2003)

Chemokines, chemokine receptors and disease : current topics in membranes /
gan: Schwiebert, Lisa M.
Cyhoeddwyd: (2005)

The role of tumour-expressed CCR6 and CCR7 in breast cancer metastasis and tumour immunity
gan: Tang, Kai Xin
Cyhoeddwyd: (2020)

ZAE 282E/3 - MATERIAL SCIENCE OKT 04
gan: PPSF, Pusat Pengajian Sains Fizik
Cyhoeddwyd: (2004)

ZAE 282E/3 - SAINS BAHAN SEP 03.
gan: PPSF, Pusat Pengajian Sains Fizik
Cyhoeddwyd: (2003)