The structure and evolution of the human beta-globin gene family.
We present the results of a detailed comparison of the primary structure of human beta-like globin genes and their flanking sequences. Among the sequences located 5' to these genes are two highly conserved regions which include the sequences ATA and CCAAT located 31 +/- 1 and 77 +/- 10 bp, resp...
| Главные авторы: | , , , , , , , , , , , , , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
1980
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| _version_ | 1826285471291932672 |
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| author | Efstratiadis, A Posakony, J Maniatis, T Lawn, R O'Connell, C Spritz, R DeRiel, J Forget, BG Weissman, S Slightom, J Blechl, A Smithies, O Baralle, F Shoulders, C Proudfoot, N |
| author_facet | Efstratiadis, A Posakony, J Maniatis, T Lawn, R O'Connell, C Spritz, R DeRiel, J Forget, BG Weissman, S Slightom, J Blechl, A Smithies, O Baralle, F Shoulders, C Proudfoot, N |
| author_sort | Efstratiadis, A |
| collection | OXFORD |
| description | We present the results of a detailed comparison of the primary structure of human beta-like globin genes and their flanking sequences. Among the sequences located 5' to these genes are two highly conserved regions which include the sequences ATA and CCAAT located 31 +/- 1 and 77 +/- 10 bp, respectively, 5' to the mRNA capping site. Similar sequences are found in the corresponding locations in most other eucaryotic structural genes. Calculation of the divergence times of individual beta-like globin gene pairs provides the first description of the evolutionary relationships within a gene family based entirely on direct nucleotide sequence comparisons. In addition, the evolutionary relationship of the embryonic epsilon-globin gene to the other human beta-like globin genes is defined for the first time. Finally, we describe a model for the involvement of short direct repeat sequences in the generation of deletions in the noncoding and coding regions of beta-like globin genes during evolution. |
| first_indexed | 2024-03-07T01:29:20Z |
| format | Journal article |
| id | oxford-uuid:93140ddb-aeaa-4f2f-bab0-8391b88b1c68 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:29:20Z |
| publishDate | 1980 |
| record_format | dspace |
| spelling | oxford-uuid:93140ddb-aeaa-4f2f-bab0-8391b88b1c682022-03-26T23:29:48ZThe structure and evolution of the human beta-globin gene family.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:93140ddb-aeaa-4f2f-bab0-8391b88b1c68EnglishSymplectic Elements at Oxford1980Efstratiadis, APosakony, JManiatis, TLawn, RO'Connell, CSpritz, RDeRiel, JForget, BGWeissman, SSlightom, JBlechl, ASmithies, OBaralle, FShoulders, CProudfoot, NWe present the results of a detailed comparison of the primary structure of human beta-like globin genes and their flanking sequences. Among the sequences located 5' to these genes are two highly conserved regions which include the sequences ATA and CCAAT located 31 +/- 1 and 77 +/- 10 bp, respectively, 5' to the mRNA capping site. Similar sequences are found in the corresponding locations in most other eucaryotic structural genes. Calculation of the divergence times of individual beta-like globin gene pairs provides the first description of the evolutionary relationships within a gene family based entirely on direct nucleotide sequence comparisons. In addition, the evolutionary relationship of the embryonic epsilon-globin gene to the other human beta-like globin genes is defined for the first time. Finally, we describe a model for the involvement of short direct repeat sequences in the generation of deletions in the noncoding and coding regions of beta-like globin genes during evolution. |
| spellingShingle | Efstratiadis, A Posakony, J Maniatis, T Lawn, R O'Connell, C Spritz, R DeRiel, J Forget, BG Weissman, S Slightom, J Blechl, A Smithies, O Baralle, F Shoulders, C Proudfoot, N The structure and evolution of the human beta-globin gene family. |
| title | The structure and evolution of the human beta-globin gene family. |
| title_full | The structure and evolution of the human beta-globin gene family. |
| title_fullStr | The structure and evolution of the human beta-globin gene family. |
| title_full_unstemmed | The structure and evolution of the human beta-globin gene family. |
| title_short | The structure and evolution of the human beta-globin gene family. |
| title_sort | structure and evolution of the human beta globin gene family |
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