An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation.

A T helper cell type 1-mediated colitis develops in severe combined immunodeficient mice after transfer of CD45RB(high) CD4(+) T cells and can be prevented by cotransfer of the CD45RB(low) subset. The immune-suppressive activities of the CD45RB(low) T cell population can be reversed in vivo by admin...

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Autori principali: Asseman, C, Mauze, S, Leach, M, Coffman, R, Powrie, F
Natura: Journal article
Lingua:English
Pubblicazione: 1999