The benzodiazepine antagonist, Ro 15-1788 does not decrease ethanol withdrawal convulsions in rats.
The effects of the benzodiazepine antagonist, Ro 15-1788 on ethanol withdrawal convulsions were investigated in rats. The study originated from recent reports of benzodiazepine binding activity in urine of alcoholics during withdrawal. No alleviation of convulsions was found with Ro 15-1788. This su...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1985
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| _version_ | 1797082570441097216 |
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| author | Little, H Taylor, S Nutt, D Cowen, P |
| author_facet | Little, H Taylor, S Nutt, D Cowen, P |
| author_sort | Little, H |
| collection | OXFORD |
| description | The effects of the benzodiazepine antagonist, Ro 15-1788 on ethanol withdrawal convulsions were investigated in rats. The study originated from recent reports of benzodiazepine binding activity in urine of alcoholics during withdrawal. No alleviation of convulsions was found with Ro 15-1788. This suggested that this component of the withdrawal syndrome is not due to endogenous production of a benzodiazepine inverse agonist (contragonist), as Ro 15-1788 prevents the action of this type of compound. |
| first_indexed | 2024-03-07T01:29:48Z |
| format | Journal article |
| id | oxford-uuid:93371dd8-235b-44d6-83a9-786b993273e1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:29:48Z |
| publishDate | 1985 |
| record_format | dspace |
| spelling | oxford-uuid:93371dd8-235b-44d6-83a9-786b993273e12022-03-26T23:30:41ZThe benzodiazepine antagonist, Ro 15-1788 does not decrease ethanol withdrawal convulsions in rats.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:93371dd8-235b-44d6-83a9-786b993273e1EnglishSymplectic Elements at Oxford1985Little, HTaylor, SNutt, DCowen, PThe effects of the benzodiazepine antagonist, Ro 15-1788 on ethanol withdrawal convulsions were investigated in rats. The study originated from recent reports of benzodiazepine binding activity in urine of alcoholics during withdrawal. No alleviation of convulsions was found with Ro 15-1788. This suggested that this component of the withdrawal syndrome is not due to endogenous production of a benzodiazepine inverse agonist (contragonist), as Ro 15-1788 prevents the action of this type of compound. |
| spellingShingle | Little, H Taylor, S Nutt, D Cowen, P The benzodiazepine antagonist, Ro 15-1788 does not decrease ethanol withdrawal convulsions in rats. |
| title | The benzodiazepine antagonist, Ro 15-1788 does not decrease ethanol withdrawal convulsions in rats. |
| title_full | The benzodiazepine antagonist, Ro 15-1788 does not decrease ethanol withdrawal convulsions in rats. |
| title_fullStr | The benzodiazepine antagonist, Ro 15-1788 does not decrease ethanol withdrawal convulsions in rats. |
| title_full_unstemmed | The benzodiazepine antagonist, Ro 15-1788 does not decrease ethanol withdrawal convulsions in rats. |
| title_short | The benzodiazepine antagonist, Ro 15-1788 does not decrease ethanol withdrawal convulsions in rats. |
| title_sort | benzodiazepine antagonist ro 15 1788 does not decrease ethanol withdrawal convulsions in rats |
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