The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis.

The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis.

The Bcl-2-associated X protein (Bax) and Bcl-2-antagonist/killer (Bak) are essential regulators of lymphocyte apoptosis, but whether they play a role in viable T cell function remains unclear. Here, we report that T cells lacking both Bax and Bak display defects in antigen-specific proliferation bec...

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Bibliographic Details
Main Authors: Jones, R, Bui, T, White, C, Madesh, M, Krawczyk, C, Lindsten, T, Hawkins, B, Kubek, S, Frauwirth, K, Wang, Y, Conway, S, Roderick, H, Bootman, MD, Shen, H, Foskett, J, Thompson, C
Format: Journal article
Language:English
Published: 2007

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