Emerging principles for the therapeutic exploitation of glycosylation.
Glycosylation plays a key role in a wide range of biological processes. Specific modification to a glycan's structure can directly modulate its biological function. Glycans are not only essential to glycoprotein folding, cellular homeostasis, and immune regulation but are involved in multiple d...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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American Association for the Advancement of Science
2014
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| _version_ | 1797082616375017472 |
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| author | Dalziel, M Crispin, M Scanlan, C Zitzmann, N Dwek, R |
| author_facet | Dalziel, M Crispin, M Scanlan, C Zitzmann, N Dwek, R |
| author_sort | Dalziel, M |
| collection | OXFORD |
| description | Glycosylation plays a key role in a wide range of biological processes. Specific modification to a glycan's structure can directly modulate its biological function. Glycans are not only essential to glycoprotein folding, cellular homeostasis, and immune regulation but are involved in multiple disease conditions. An increased molecular and structural understanding of the mechanistic role that glycans play in these pathological processes has driven the development of therapeutics and illuminated novel targets for drug design. This knowledge has enabled the treatment of metabolic disorders and the development of antivirals and shaped cancer and viral vaccine strategies. Furthermore, an understanding of glycosylation has led to the development of specific drug glycoforms, for example, monoclonal antibodies, with enhanced potency. |
| first_indexed | 2024-03-07T01:30:17Z |
| format | Journal article |
| id | oxford-uuid:9360625a-b514-4d25-9a06-8ccdadf9e376 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:30:17Z |
| publishDate | 2014 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:9360625a-b514-4d25-9a06-8ccdadf9e3762022-03-26T23:31:51ZEmerging principles for the therapeutic exploitation of glycosylation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9360625a-b514-4d25-9a06-8ccdadf9e376EnglishSymplectic Elements at OxfordAmerican Association for the Advancement of Science2014Dalziel, MCrispin, MScanlan, CZitzmann, NDwek, RGlycosylation plays a key role in a wide range of biological processes. Specific modification to a glycan's structure can directly modulate its biological function. Glycans are not only essential to glycoprotein folding, cellular homeostasis, and immune regulation but are involved in multiple disease conditions. An increased molecular and structural understanding of the mechanistic role that glycans play in these pathological processes has driven the development of therapeutics and illuminated novel targets for drug design. This knowledge has enabled the treatment of metabolic disorders and the development of antivirals and shaped cancer and viral vaccine strategies. Furthermore, an understanding of glycosylation has led to the development of specific drug glycoforms, for example, monoclonal antibodies, with enhanced potency. |
| spellingShingle | Dalziel, M Crispin, M Scanlan, C Zitzmann, N Dwek, R Emerging principles for the therapeutic exploitation of glycosylation. |
| title | Emerging principles for the therapeutic exploitation of glycosylation. |
| title_full | Emerging principles for the therapeutic exploitation of glycosylation. |
| title_fullStr | Emerging principles for the therapeutic exploitation of glycosylation. |
| title_full_unstemmed | Emerging principles for the therapeutic exploitation of glycosylation. |
| title_short | Emerging principles for the therapeutic exploitation of glycosylation. |
| title_sort | emerging principles for the therapeutic exploitation of glycosylation |
| work_keys_str_mv | AT dalzielm emergingprinciplesforthetherapeuticexploitationofglycosylation AT crispinm emergingprinciplesforthetherapeuticexploitationofglycosylation AT scanlanc emergingprinciplesforthetherapeuticexploitationofglycosylation AT zitzmannn emergingprinciplesforthetherapeuticexploitationofglycosylation AT dwekr emergingprinciplesforthetherapeuticexploitationofglycosylation |