The role of tenascin-C in tissue injury and tumorigenesis.
The extracellular matrix molecule tenascin-C is highly expressed during embryonic development, tissue repair and in pathological situations such as chronic inflammation and cancer. Tenascin-C interacts with several other extracellular matrix molecules and cell-surface receptors, thus affecting tissu...
| मुख्य लेखकों: | , |
|---|---|
| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2009
|
| _version_ | 1826285536266944512 |
|---|---|
| author | Midwood, K Orend, G |
| author_facet | Midwood, K Orend, G |
| author_sort | Midwood, K |
| collection | OXFORD |
| description | The extracellular matrix molecule tenascin-C is highly expressed during embryonic development, tissue repair and in pathological situations such as chronic inflammation and cancer. Tenascin-C interacts with several other extracellular matrix molecules and cell-surface receptors, thus affecting tissue architecture, tissue resilience and cell responses. Tenascin-C modulates cell migration, proliferation and cellular signaling through induction of pro-inflammatory cytokines and oncogenic signaling molecules amongst other mechanisms. Given the causal role of inflammation in cancer progression, common mechanisms might be controlled by tenascin-C during both events. Drugs targeting the expression or function of tenascin-C or the tenascin-C protein itself are currently being developed and some drugs have already reached advanced clinical trials. This generates hope that increased knowledge about tenascin-C will further improve management of diseases with high tenascin-C expression such as chronic inflammation, heart failure, artheriosclerosis and cancer. |
| first_indexed | 2024-03-07T01:30:17Z |
| format | Journal article |
| id | oxford-uuid:93606918-67a9-4e17-9d8b-a9d3dbfb878a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:30:17Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:93606918-67a9-4e17-9d8b-a9d3dbfb878a2022-03-26T23:31:49ZThe role of tenascin-C in tissue injury and tumorigenesis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:93606918-67a9-4e17-9d8b-a9d3dbfb878aEnglishSymplectic Elements at Oxford2009Midwood, KOrend, GThe extracellular matrix molecule tenascin-C is highly expressed during embryonic development, tissue repair and in pathological situations such as chronic inflammation and cancer. Tenascin-C interacts with several other extracellular matrix molecules and cell-surface receptors, thus affecting tissue architecture, tissue resilience and cell responses. Tenascin-C modulates cell migration, proliferation and cellular signaling through induction of pro-inflammatory cytokines and oncogenic signaling molecules amongst other mechanisms. Given the causal role of inflammation in cancer progression, common mechanisms might be controlled by tenascin-C during both events. Drugs targeting the expression or function of tenascin-C or the tenascin-C protein itself are currently being developed and some drugs have already reached advanced clinical trials. This generates hope that increased knowledge about tenascin-C will further improve management of diseases with high tenascin-C expression such as chronic inflammation, heart failure, artheriosclerosis and cancer. |
| spellingShingle | Midwood, K Orend, G The role of tenascin-C in tissue injury and tumorigenesis. |
| title | The role of tenascin-C in tissue injury and tumorigenesis. |
| title_full | The role of tenascin-C in tissue injury and tumorigenesis. |
| title_fullStr | The role of tenascin-C in tissue injury and tumorigenesis. |
| title_full_unstemmed | The role of tenascin-C in tissue injury and tumorigenesis. |
| title_short | The role of tenascin-C in tissue injury and tumorigenesis. |
| title_sort | role of tenascin c in tissue injury and tumorigenesis |
| work_keys_str_mv | AT midwoodk theroleoftenascincintissueinjuryandtumorigenesis AT orendg theroleoftenascincintissueinjuryandtumorigenesis AT midwoodk roleoftenascincintissueinjuryandtumorigenesis AT orendg roleoftenascincintissueinjuryandtumorigenesis |