An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer.
Inflammatory bowel disease (IBD) is characterized by dysregulated immune responses to the intestinal microbiota, and by chronic intestinal inflammation. Several recent studies demonstrate the importance of innate microbial recognition by immune and nonimmune cells in the gut. Paradoxically, either d...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1797082631833124864 |
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| author | Asquith, M Powrie, F |
| author_facet | Asquith, M Powrie, F |
| author_sort | Asquith, M |
| collection | OXFORD |
| description | Inflammatory bowel disease (IBD) is characterized by dysregulated immune responses to the intestinal microbiota, and by chronic intestinal inflammation. Several recent studies demonstrate the importance of innate microbial recognition by immune and nonimmune cells in the gut. Paradoxically, either diminished or exacerbated innate immune signaling may trigger the breakdown of intestinal homeostasis, leading to IBD and colitis-associated cancer (CAC). This dichotomy may reflect divergent functional roles for immune sensing in intestinal epithelial cells and leukocytes, which may vary with distinct disease mechanisms. |
| first_indexed | 2024-03-07T01:30:28Z |
| format | Journal article |
| id | oxford-uuid:936cfb3c-6dba-4d87-94d9-c71f34fbd17f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:30:28Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:936cfb3c-6dba-4d87-94d9-c71f34fbd17f2022-03-26T23:32:11ZAn innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:936cfb3c-6dba-4d87-94d9-c71f34fbd17fEnglishSymplectic Elements at Oxford2010Asquith, MPowrie, FInflammatory bowel disease (IBD) is characterized by dysregulated immune responses to the intestinal microbiota, and by chronic intestinal inflammation. Several recent studies demonstrate the importance of innate microbial recognition by immune and nonimmune cells in the gut. Paradoxically, either diminished or exacerbated innate immune signaling may trigger the breakdown of intestinal homeostasis, leading to IBD and colitis-associated cancer (CAC). This dichotomy may reflect divergent functional roles for immune sensing in intestinal epithelial cells and leukocytes, which may vary with distinct disease mechanisms. |
| spellingShingle | Asquith, M Powrie, F An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer. |
| title | An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer. |
| title_full | An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer. |
| title_fullStr | An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer. |
| title_full_unstemmed | An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer. |
| title_short | An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer. |
| title_sort | innately dangerous balancing act intestinal homeostasis inflammation and colitis associated cancer |
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