Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.

Isopenicillin N synthase (IPNS) is a non-heme iron(II) oxidase which catalyses the biosynthesis of isopenicillin N (IPN) from the tripeptide delta-l-alpha-aminoadipoyl-l-cysteinyl-d-valine (lld-ACV). Herein we report crystallographic studies to investigate the binding of a truncated lll-substrate in...

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מידע ביבליוגרפי
Main Authors: Ge, W, Clifton, I, Stok, J, Adlington, R, Baldwin, J, Rutledge, P
פורמט: Journal article
שפה:English
יצא לאור: 2010