Effects of seven-day diazepam administration on resting-state functional connectivity in healthy volunteers: a randomized, double-blind study.
RATIONALE: Benzodiazepines, such as diazepam, are anxiolytic-sedative drugs, used for the treatment of several different disorders. The pharmacological mechanism of action of benzodiazepines is well understood; however, it remains unclear which neural networks and systems are involved in translating...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Berlin Heidelberg
2014
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| _version_ | 1797082661677694976 |
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| author | Pflanz, C Pringle, A Filippini, N Warren, M Gottwald, J Cowen, P Harmer, C |
| author_facet | Pflanz, C Pringle, A Filippini, N Warren, M Gottwald, J Cowen, P Harmer, C |
| author_sort | Pflanz, C |
| collection | OXFORD |
| description | RATIONALE: Benzodiazepines, such as diazepam, are anxiolytic-sedative drugs, used for the treatment of several different disorders. The pharmacological mechanism of action of benzodiazepines is well understood; however, it remains unclear which neural networks and systems are involved in translating these neurochemical actions into their therapeutic effects. OBJECTIVES: The objective of this study was to investigate the effects of 7-day diazepam administration compared to placebo on resting-state functional connectivity in healthy adults independent of any task. METHODS: Thirty-four healthy participants were randomly assigned to receive either diazepam (N = 17) or placebo (15 mg daily for 7 days) and underwent resting-state functional magnetic resonance acquisition. Model-free data analysis was performed using independent component analysis and dual regression. RESULTS: Consistent with previous research, 11 resting-state networks were identified. Increased connectivity in response to diazepam administration was found in the medial visual network and middle/inferior temporal network. Diazepam did not cause any decreases in functional connectivity. CONCLUSIONS: Diazepam administration increases functional connectivity in areas of emotional processing independent of any task. Diazepam also enhanced functional connectivity in the medial visual system, which is a brain region rich in GABAA receptors, and shows high binding of GABAergic drugs. These increases in functional connectivity are characteristic of CNS depressants. |
| first_indexed | 2024-03-07T01:30:55Z |
| format | Journal article |
| id | oxford-uuid:939186c0-8b82-47bf-9f76-2efe9aab1557 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:30:55Z |
| publishDate | 2014 |
| publisher | Springer Berlin Heidelberg |
| record_format | dspace |
| spelling | oxford-uuid:939186c0-8b82-47bf-9f76-2efe9aab15572022-03-26T23:33:15ZEffects of seven-day diazepam administration on resting-state functional connectivity in healthy volunteers: a randomized, double-blind study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:939186c0-8b82-47bf-9f76-2efe9aab1557EnglishSymplectic Elements at OxfordSpringer Berlin Heidelberg2014Pflanz, CPringle, AFilippini, NWarren, MGottwald, JCowen, PHarmer, CRATIONALE: Benzodiazepines, such as diazepam, are anxiolytic-sedative drugs, used for the treatment of several different disorders. The pharmacological mechanism of action of benzodiazepines is well understood; however, it remains unclear which neural networks and systems are involved in translating these neurochemical actions into their therapeutic effects. OBJECTIVES: The objective of this study was to investigate the effects of 7-day diazepam administration compared to placebo on resting-state functional connectivity in healthy adults independent of any task. METHODS: Thirty-four healthy participants were randomly assigned to receive either diazepam (N = 17) or placebo (15 mg daily for 7 days) and underwent resting-state functional magnetic resonance acquisition. Model-free data analysis was performed using independent component analysis and dual regression. RESULTS: Consistent with previous research, 11 resting-state networks were identified. Increased connectivity in response to diazepam administration was found in the medial visual network and middle/inferior temporal network. Diazepam did not cause any decreases in functional connectivity. CONCLUSIONS: Diazepam administration increases functional connectivity in areas of emotional processing independent of any task. Diazepam also enhanced functional connectivity in the medial visual system, which is a brain region rich in GABAA receptors, and shows high binding of GABAergic drugs. These increases in functional connectivity are characteristic of CNS depressants. |
| spellingShingle | Pflanz, C Pringle, A Filippini, N Warren, M Gottwald, J Cowen, P Harmer, C Effects of seven-day diazepam administration on resting-state functional connectivity in healthy volunteers: a randomized, double-blind study. |
| title | Effects of seven-day diazepam administration on resting-state functional connectivity in healthy volunteers: a randomized, double-blind study. |
| title_full | Effects of seven-day diazepam administration on resting-state functional connectivity in healthy volunteers: a randomized, double-blind study. |
| title_fullStr | Effects of seven-day diazepam administration on resting-state functional connectivity in healthy volunteers: a randomized, double-blind study. |
| title_full_unstemmed | Effects of seven-day diazepam administration on resting-state functional connectivity in healthy volunteers: a randomized, double-blind study. |
| title_short | Effects of seven-day diazepam administration on resting-state functional connectivity in healthy volunteers: a randomized, double-blind study. |
| title_sort | effects of seven day diazepam administration on resting state functional connectivity in healthy volunteers a randomized double blind study |
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