Case report: meningitis as a presenting feature of anti-NMDA receptor encephalitis
BACKGROUND:Meningitis is a very rare atypical presenting feature of anti-NMDA receptor encephalitis. In our case report, we describe an unusual clinical presentation of anti-NMDA receptor encephalitis with a biphasic pattern of meningitis followed by encephalitis and discuss potential mechanisms und...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
BioMed Central
2020
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| _version_ | 1797082698516267008 |
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| author | Stavrou, M Yeo, JM Slater, AD Koch, O Irani, S Foley, P |
| author_facet | Stavrou, M Yeo, JM Slater, AD Koch, O Irani, S Foley, P |
| author_sort | Stavrou, M |
| collection | OXFORD |
| description | BACKGROUND:Meningitis is a very rare atypical presenting feature of anti-NMDA receptor encephalitis. In our case report, we describe an unusual clinical presentation of anti-NMDA receptor encephalitis with a biphasic pattern of meningitis followed by encephalitis and discuss potential mechanisms underlying this presentation. We aim to widen the differential diagnosis to be considered in a patient presenting with clinical meningitis and pyrexia.
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CASE PRESENTATION:This is a case of a 33-year old Caucasian woman who initially presented with a lymphocytic meningitis attributed to a viral infection. She subsequently developed fluctuating consciousness, agitation, visual hallucinations, dyskinetic movements, a generalized tonic-clonic seizure, and autonomic instability. Investigations revealed a diagnosis of anti-NMDA receptor encephalitis secondary to a previously unidentified ovarian teratoma. She made an excellent recovery with immunotherapy and removal of the teratoma.
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CONCLUSION:Clinicians should consider autoimmune encephalitides in individuals with meningitis, particularly where extensive investigations fail to identify a causative pathogen and there is rapid development of an encephalitic phenotype. |
| first_indexed | 2024-03-07T01:31:28Z |
| format | Journal article |
| id | oxford-uuid:93c107c2-a5a2-46a8-a470-b6e45a5f653c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:31:28Z |
| publishDate | 2020 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:93c107c2-a5a2-46a8-a470-b6e45a5f653c2022-03-26T23:34:28ZCase report: meningitis as a presenting feature of anti-NMDA receptor encephalitisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:93c107c2-a5a2-46a8-a470-b6e45a5f653cEnglishSymplectic ElementsBioMed Central 2020Stavrou, MYeo, JMSlater, ADKoch, OIrani, SFoley, PBACKGROUND:Meningitis is a very rare atypical presenting feature of anti-NMDA receptor encephalitis. In our case report, we describe an unusual clinical presentation of anti-NMDA receptor encephalitis with a biphasic pattern of meningitis followed by encephalitis and discuss potential mechanisms underlying this presentation. We aim to widen the differential diagnosis to be considered in a patient presenting with clinical meningitis and pyrexia. <br><br> CASE PRESENTATION:This is a case of a 33-year old Caucasian woman who initially presented with a lymphocytic meningitis attributed to a viral infection. She subsequently developed fluctuating consciousness, agitation, visual hallucinations, dyskinetic movements, a generalized tonic-clonic seizure, and autonomic instability. Investigations revealed a diagnosis of anti-NMDA receptor encephalitis secondary to a previously unidentified ovarian teratoma. She made an excellent recovery with immunotherapy and removal of the teratoma. <br><br> CONCLUSION:Clinicians should consider autoimmune encephalitides in individuals with meningitis, particularly where extensive investigations fail to identify a causative pathogen and there is rapid development of an encephalitic phenotype. |
| spellingShingle | Stavrou, M Yeo, JM Slater, AD Koch, O Irani, S Foley, P Case report: meningitis as a presenting feature of anti-NMDA receptor encephalitis |
| title | Case report: meningitis as a presenting feature of anti-NMDA receptor encephalitis |
| title_full | Case report: meningitis as a presenting feature of anti-NMDA receptor encephalitis |
| title_fullStr | Case report: meningitis as a presenting feature of anti-NMDA receptor encephalitis |
| title_full_unstemmed | Case report: meningitis as a presenting feature of anti-NMDA receptor encephalitis |
| title_short | Case report: meningitis as a presenting feature of anti-NMDA receptor encephalitis |
| title_sort | case report meningitis as a presenting feature of anti nmda receptor encephalitis |
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