Short-term ionic plasticity at GABAergic synapses.
Fast synaptic inhibition in the brain is mediated by the pre-synaptic release of the neurotransmitter γ-Aminobutyric acid (GABA)and the post-synaptic activation of GABA-sensitive ionotropic receptors. As with excitatory synapses, it is being increasinly appreciated that a variety of plastic processe...
| Główni autorzy: | , , |
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| Format: | Journal article |
| Język: | English |
| Wydane: |
2012
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| _version_ | 1826285649031856128 |
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| author | Raimondo, J Markram, H Akerman, C |
| author_facet | Raimondo, J Markram, H Akerman, C |
| author_sort | Raimondo, J |
| collection | OXFORD |
| description | Fast synaptic inhibition in the brain is mediated by the pre-synaptic release of the neurotransmitter γ-Aminobutyric acid (GABA)and the post-synaptic activation of GABA-sensitive ionotropic receptors. As with excitatory synapses, it is being increasinly appreciated that a variety of plastic processes occur at inhibitory synapses, which operate over a range of timescales. Here we examine a form of activity-dependent plasticity that is somewhat unique to GABAergic transmission. This involves short-lasting changes to the ionic driving force for the post-synaptic receptors, a process referred to as short-term ionic plasticity. These changes are directly related to the history of activity at inhibitory synapses and are influenced by a variety of factors including the location of the synapse and the post-synaptic cell's ion regulation mechanisms. We explore the processes underlying this form of plasticity, when and where it can occur, and how it is likely to impact network activity. |
| first_indexed | 2024-03-07T01:31:59Z |
| format | Journal article |
| id | oxford-uuid:93e77bf9-c1de-4203-b423-0a70a8d4073c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:31:59Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:93e77bf9-c1de-4203-b423-0a70a8d4073c2022-03-26T23:35:33ZShort-term ionic plasticity at GABAergic synapses.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:93e77bf9-c1de-4203-b423-0a70a8d4073cEnglishSymplectic Elements at Oxford2012Raimondo, JMarkram, HAkerman, CFast synaptic inhibition in the brain is mediated by the pre-synaptic release of the neurotransmitter γ-Aminobutyric acid (GABA)and the post-synaptic activation of GABA-sensitive ionotropic receptors. As with excitatory synapses, it is being increasinly appreciated that a variety of plastic processes occur at inhibitory synapses, which operate over a range of timescales. Here we examine a form of activity-dependent plasticity that is somewhat unique to GABAergic transmission. This involves short-lasting changes to the ionic driving force for the post-synaptic receptors, a process referred to as short-term ionic plasticity. These changes are directly related to the history of activity at inhibitory synapses and are influenced by a variety of factors including the location of the synapse and the post-synaptic cell's ion regulation mechanisms. We explore the processes underlying this form of plasticity, when and where it can occur, and how it is likely to impact network activity. |
| spellingShingle | Raimondo, J Markram, H Akerman, C Short-term ionic plasticity at GABAergic synapses. |
| title | Short-term ionic plasticity at GABAergic synapses. |
| title_full | Short-term ionic plasticity at GABAergic synapses. |
| title_fullStr | Short-term ionic plasticity at GABAergic synapses. |
| title_full_unstemmed | Short-term ionic plasticity at GABAergic synapses. |
| title_short | Short-term ionic plasticity at GABAergic synapses. |
| title_sort | short term ionic plasticity at gabaergic synapses |
| work_keys_str_mv | AT raimondoj shorttermionicplasticityatgabaergicsynapses AT markramh shorttermionicplasticityatgabaergicsynapses AT akermanc shorttermionicplasticityatgabaergicsynapses |