The association between dietary flavonoid and lignan intakes and incident type 2 diabetes in European populations: the EPIC-InterAct study.
OBJECTIVE: To study the association between dietary flavonoid and lignan intakes, and the risk of development of type 2 diabetes among European populations. RESEARCH DESIGN AND METHODS: The European Prospective Investigation into Cancer and Nutrition-InterAct case-cohort study included 12,403 incide...
| Glavni autori: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Jezik: | English |
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2013
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| _version_ | 1826285672081653760 |
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| author | Zamora-Ros, R Forouhi, N Sharp, S González, C Buijsse, B Guevara, M van der Schouw, Y Amiano, P Boeing, H Bredsdorff, L Clavel-Chapelon, F Fagherazzi, G Feskens, E Franks, P Grioni, S Katzke, V Key, T Khaw, K Kühn, T Masala, G Mattiello, A Molina-Montes, E Nilsson, P Overvad, K Perquier, F |
| author_facet | Zamora-Ros, R Forouhi, N Sharp, S González, C Buijsse, B Guevara, M van der Schouw, Y Amiano, P Boeing, H Bredsdorff, L Clavel-Chapelon, F Fagherazzi, G Feskens, E Franks, P Grioni, S Katzke, V Key, T Khaw, K Kühn, T Masala, G Mattiello, A Molina-Montes, E Nilsson, P Overvad, K Perquier, F |
| author_sort | Zamora-Ros, R |
| collection | OXFORD |
| description | OBJECTIVE: To study the association between dietary flavonoid and lignan intakes, and the risk of development of type 2 diabetes among European populations. RESEARCH DESIGN AND METHODS: The European Prospective Investigation into Cancer and Nutrition-InterAct case-cohort study included 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 participants from among 340,234 participants with 3.99 million person-years of follow-up in eight European countries. At baseline, country-specific validated dietary questionnaires were used. A flavonoid and lignan food composition database was developed from the Phenol-Explorer, the U.K. Food Standards Agency, and the U.S. Department of Agriculture databases. Hazard ratios (HRs) from country-specific Prentice-weighted Cox regression models were pooled using random-effects meta-analysis. RESULTS: In multivariable models, a trend for an inverse association between total flavonoid intake and type 2 diabetes was observed (HR for the highest vs. the lowest quintile, 0.90 [95% CI 0.77-1.04]; P value trend = 0.040), but not with lignans (HR 0.88 [95% CI 0.72-1.07]; P value trend = 0.119). Among flavonoid subclasses, flavonols (HR 0.81 [95% CI 0.69-0.95]; P value trend = 0.020) and flavanols (HR 0.82 [95% CI 0.68-0.99]; P value trend = 0.012), including flavan-3-ol monomers (HR 0.73 [95% CI 0.57-0.93]; P value trend = 0.029), were associated with a significantly reduced hazard of diabetes. CONCLUSIONS: Prospective findings in this large European cohort demonstrate inverse associations between flavonoids, particularly flavanols and flavonols, and incident type 2 diabetes. This suggests a potential protective role of eating a diet rich in flavonoids, a dietary pattern based on plant-based foods, in the prevention of type 2 diabetes. |
| first_indexed | 2024-03-07T01:32:20Z |
| format | Journal article |
| id | oxford-uuid:9404b61e-76e8-42f0-bd13-0b133f8402f6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:32:20Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:9404b61e-76e8-42f0-bd13-0b133f8402f62022-03-26T23:36:22ZThe association between dietary flavonoid and lignan intakes and incident type 2 diabetes in European populations: the EPIC-InterAct study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9404b61e-76e8-42f0-bd13-0b133f8402f6EnglishSymplectic Elements at Oxford2013Zamora-Ros, RForouhi, NSharp, SGonzález, CBuijsse, BGuevara, Mvan der Schouw, YAmiano, PBoeing, HBredsdorff, LClavel-Chapelon, FFagherazzi, GFeskens, EFranks, PGrioni, SKatzke, VKey, TKhaw, KKühn, TMasala, GMattiello, AMolina-Montes, ENilsson, POvervad, KPerquier, FOBJECTIVE: To study the association between dietary flavonoid and lignan intakes, and the risk of development of type 2 diabetes among European populations. RESEARCH DESIGN AND METHODS: The European Prospective Investigation into Cancer and Nutrition-InterAct case-cohort study included 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 participants from among 340,234 participants with 3.99 million person-years of follow-up in eight European countries. At baseline, country-specific validated dietary questionnaires were used. A flavonoid and lignan food composition database was developed from the Phenol-Explorer, the U.K. Food Standards Agency, and the U.S. Department of Agriculture databases. Hazard ratios (HRs) from country-specific Prentice-weighted Cox regression models were pooled using random-effects meta-analysis. RESULTS: In multivariable models, a trend for an inverse association between total flavonoid intake and type 2 diabetes was observed (HR for the highest vs. the lowest quintile, 0.90 [95% CI 0.77-1.04]; P value trend = 0.040), but not with lignans (HR 0.88 [95% CI 0.72-1.07]; P value trend = 0.119). Among flavonoid subclasses, flavonols (HR 0.81 [95% CI 0.69-0.95]; P value trend = 0.020) and flavanols (HR 0.82 [95% CI 0.68-0.99]; P value trend = 0.012), including flavan-3-ol monomers (HR 0.73 [95% CI 0.57-0.93]; P value trend = 0.029), were associated with a significantly reduced hazard of diabetes. CONCLUSIONS: Prospective findings in this large European cohort demonstrate inverse associations between flavonoids, particularly flavanols and flavonols, and incident type 2 diabetes. This suggests a potential protective role of eating a diet rich in flavonoids, a dietary pattern based on plant-based foods, in the prevention of type 2 diabetes. |
| spellingShingle | Zamora-Ros, R Forouhi, N Sharp, S González, C Buijsse, B Guevara, M van der Schouw, Y Amiano, P Boeing, H Bredsdorff, L Clavel-Chapelon, F Fagherazzi, G Feskens, E Franks, P Grioni, S Katzke, V Key, T Khaw, K Kühn, T Masala, G Mattiello, A Molina-Montes, E Nilsson, P Overvad, K Perquier, F The association between dietary flavonoid and lignan intakes and incident type 2 diabetes in European populations: the EPIC-InterAct study. |
| title | The association between dietary flavonoid and lignan intakes and incident type 2 diabetes in European populations: the EPIC-InterAct study. |
| title_full | The association between dietary flavonoid and lignan intakes and incident type 2 diabetes in European populations: the EPIC-InterAct study. |
| title_fullStr | The association between dietary flavonoid and lignan intakes and incident type 2 diabetes in European populations: the EPIC-InterAct study. |
| title_full_unstemmed | The association between dietary flavonoid and lignan intakes and incident type 2 diabetes in European populations: the EPIC-InterAct study. |
| title_short | The association between dietary flavonoid and lignan intakes and incident type 2 diabetes in European populations: the EPIC-InterAct study. |
| title_sort | association between dietary flavonoid and lignan intakes and incident type 2 diabetes in european populations the epic interact study |
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