The relationship between insulin, IGF-I and weight gain in cystic fibrosis.
OBJECTIVE: In cystic fibrosis, reduced body mass is related to low levels of IGF-I and changes in the IGF binding proteins. Our aim was to determine whether these abnormalities are linked to pancreatic endocrine dysfunction. PATIENTS AND DESIGN: We measured serum levels of insulin, IGF-I, IGFBP-I, I...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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| _version_ | 1797082774471966720 |
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| author | Taylor, A Thomson, A Bruce-Morgan, C Ahmed, M Watts, A Harris, D Holly, J Dunger, D |
| author_facet | Taylor, A Thomson, A Bruce-Morgan, C Ahmed, M Watts, A Harris, D Holly, J Dunger, D |
| author_sort | Taylor, A |
| collection | OXFORD |
| description | OBJECTIVE: In cystic fibrosis, reduced body mass is related to low levels of IGF-I and changes in the IGF binding proteins. Our aim was to determine whether these abnormalities are linked to pancreatic endocrine dysfunction. PATIENTS AND DESIGN: We measured serum levels of insulin, IGF-I, IGFBP-I, IGFBP-3 and IGF bioactivity in 77 fasting subjects (43 male) mean age 9.6 years (range 2.99-17.98 years). Data were analysed with respect of body mass, puberty and stature and compared with control data established in the same laboratory. RESULTS: The mean height standard deviation score (SDS (SD)) was -0.54 (0.97) and the body mass index SDS -0.24 (1.09). Both body mass index SDS (r = -0.40, P = 0.0003) and IGF-I SDS (r = - 0.32, P = 0.009) declined with age. Insulin levels were also low and correlated with IGF-I and IGFBP-3 (r = 0.42, P = 0.0004, and r = 0.45, P = 0.0002, respectively) whereas levels of IGFBP-I were inversely related to those of IGF-I and insulin (r = - 0.43, P = 0. 0004, r = - 0.52, P < 0.0001). IGF bioactivity was reduced and inversely related to IGFBP-I (r = - 0.31, P = 0.009). In multiple regression analysis, body mass index SDS was negatively related to age (P < 0.0001) and positively related to insulin and IGF-I (P = 0. 04, P = 0.03, respectively). Height SDS was correlated with IGF bioactivity (P = 0.003) and negatively with IGFBP-I (P = 0.01). CONCLUSIONS: We conclude that progressive insulin deficiency may result in reduced IGF-I levels and IGF-bioactivity and may determine weight gain and statural growth in cystic fibrosis. |
| first_indexed | 2024-03-07T01:32:37Z |
| format | Journal article |
| id | oxford-uuid:9419bcbf-f132-47d1-ba26-338f74e42786 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:32:37Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:9419bcbf-f132-47d1-ba26-338f74e427862022-03-26T23:36:54ZThe relationship between insulin, IGF-I and weight gain in cystic fibrosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9419bcbf-f132-47d1-ba26-338f74e42786EnglishSymplectic Elements at Oxford1999Taylor, AThomson, ABruce-Morgan, CAhmed, MWatts, AHarris, DHolly, JDunger, DOBJECTIVE: In cystic fibrosis, reduced body mass is related to low levels of IGF-I and changes in the IGF binding proteins. Our aim was to determine whether these abnormalities are linked to pancreatic endocrine dysfunction. PATIENTS AND DESIGN: We measured serum levels of insulin, IGF-I, IGFBP-I, IGFBP-3 and IGF bioactivity in 77 fasting subjects (43 male) mean age 9.6 years (range 2.99-17.98 years). Data were analysed with respect of body mass, puberty and stature and compared with control data established in the same laboratory. RESULTS: The mean height standard deviation score (SDS (SD)) was -0.54 (0.97) and the body mass index SDS -0.24 (1.09). Both body mass index SDS (r = -0.40, P = 0.0003) and IGF-I SDS (r = - 0.32, P = 0.009) declined with age. Insulin levels were also low and correlated with IGF-I and IGFBP-3 (r = 0.42, P = 0.0004, and r = 0.45, P = 0.0002, respectively) whereas levels of IGFBP-I were inversely related to those of IGF-I and insulin (r = - 0.43, P = 0. 0004, r = - 0.52, P < 0.0001). IGF bioactivity was reduced and inversely related to IGFBP-I (r = - 0.31, P = 0.009). In multiple regression analysis, body mass index SDS was negatively related to age (P < 0.0001) and positively related to insulin and IGF-I (P = 0. 04, P = 0.03, respectively). Height SDS was correlated with IGF bioactivity (P = 0.003) and negatively with IGFBP-I (P = 0.01). CONCLUSIONS: We conclude that progressive insulin deficiency may result in reduced IGF-I levels and IGF-bioactivity and may determine weight gain and statural growth in cystic fibrosis. |
| spellingShingle | Taylor, A Thomson, A Bruce-Morgan, C Ahmed, M Watts, A Harris, D Holly, J Dunger, D The relationship between insulin, IGF-I and weight gain in cystic fibrosis. |
| title | The relationship between insulin, IGF-I and weight gain in cystic fibrosis. |
| title_full | The relationship between insulin, IGF-I and weight gain in cystic fibrosis. |
| title_fullStr | The relationship between insulin, IGF-I and weight gain in cystic fibrosis. |
| title_full_unstemmed | The relationship between insulin, IGF-I and weight gain in cystic fibrosis. |
| title_short | The relationship between insulin, IGF-I and weight gain in cystic fibrosis. |
| title_sort | relationship between insulin igf i and weight gain in cystic fibrosis |
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