Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

Post-translational hydroxylation has been considered an unusual modification on intracellular proteins. However, following the recognition that oxygen-sensitive prolyl and asparaginyl hydroxylation are central to the regulation of the transcription factor hypoxia-inducible factor (HIF), interest has...

詳細記述

書誌詳細
主要な著者: Cockman, M, Webb, J, Kramer, H, Kessler, B, Ratcliffe, P
フォーマット: Journal article
言語:English
出版事項: 2009