Characterization of 2'-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion.

Characterization of 2'-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion.

We have isolated artificial ligands or aptamers for infectious prions in order to investigate conformational aspects of prion pathogenesis. The aptamers are 2'-fluoro-modified RNA produced by in vitro selection from a large, randomized library. One of these ligands (aptamer SAF-93) had more tha...

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Bibliographic Details
Main Authors:	Rhie, A, Kirby, L, Sayer, N, Wellesley, R, Disterer, P, Sylvester, I, Gill, A, Hope, J, James, W, Tahiri-Alaoui, A
Format:	Journal article
Language:	English
Published:	2003

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