Successful targeting of the mouse cystic fibrosis transmembrane conductance regulator gene in embryonal stem cells.

Successful targeting of the mouse cystic fibrosis transmembrane conductance regulator gene in embryonal stem cells.

We wish to construct a mouse model for the human inherited disease cystic fibrosis. We describe here the successful targeting in embryonal stem cells of the murine homologue (Cftr) of the cystic fibrosis transmembrane conductance regulator gene, as the first critical step towards this end. The targe...

Podrobná bibliografie
Hlavní autoři:	Dorin, JR, Dickinson, P, Emslie, E, Clarke, A, Dobbie, L, Hooper, M, Halford, S, Wainwright, B, Porteous, D
Médium:	Journal article
Jazyk:	English
Vydáno:	Kluwer Academic Publishers 1992

Podobné jednotky

Localization of the cystic fibrosis transmembrane conductance regulator (Cftr) to mouse chromosome 6.
Autor: Siegel, D, a další
Vydáno: (1992)

Cloning the mouse homolog of the human cystic fibrosis transmembrane conductance regulator gene.
Autor: Tata, F, a další
Vydáno: (1991)

Cystic fibrosis transmembrane conductance regulator (CFTR): beyond cystic fibrosis
Autor: Giuseppe Fabio Parisi, a další
Vydáno: (2022-05-01)

Glycosylation and the cystic fibrosis transmembrane conductance regulator
Autor: Glick Mary Catherine, a další
Vydáno: (2001-08-01)

Cystic fibrosis transmembrane conductance regulator (CFTR)-targeted therapeutics for cystic fibrosis
Autor: Veselu, D-F, a další
Vydáno: (2024)

Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives
Autor: Schmidt BZ, a další
Vydáno: (2016-09-01)

Acquired cystic fibrosis transmembrane conductance regulator dysfunction
Autor: Catherine Banks, a další
Vydáno: (2018-09-01)

Structure and function of the cystic fibrosis transmembrane conductance regulator
Autor: M.M. Morales, a další
Vydáno: (1999-08-01)

Cystic fibrosis transmembrane conductance regulator biomarkers in ‘real life’: can we evaluate individual efficacy of cystic fibrosis transmembrane conductance regulator therapy?
Autor: Silke van Koningsbruggen-Rietschel, a další
Vydáno: (2015-08-01)

Paediatric Thoracic Imaging in Cystic Fibrosis in the Era of Cystic Fibrosis Transmembrane Conductance Regulator Modulation
Autor: Patrick W. O’Regan, a další
Vydáno: (2024-02-01)

Targeting a genetic defect: cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis
Autor: Nico Derichs
Vydáno: (2013-03-01)

A bibliometric analysis of cystic fibrosis transmembrane conductance regulators
Autor: Bashar Araiqat, a další
Vydáno: (2024-07-01)

A transistor model for the cystic fibrosis transmembrane conductance regulator
Autor: William D. Hunt, a další
Vydáno: (2023-06-01)

Cystic Fibrosis Transmembrane Conductance Regulator Folding Mutations Reveal Differences in Corrector Efficacy Linked to Increases in Immature Cystic Fibrosis Transmembrane Conductance Regulator Expression
Autor: Kathryn W. Peters, a další
Vydáno: (2021-10-01)

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitylation as a Novel Pharmaceutical Target for Cystic Fibrosis
Autor: Ryosuke Fukuda, a další
Vydáno: (2020-04-01)

A Developmental Role of the Cystic Fibrosis Transmembrane Conductance Regulator in Cystic Fibrosis Lung Disease Pathogenesis
Autor: Elena N. Huang, a další
Vydáno: (2021-10-01)

Eligibility of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulator therapies: cohort of cystic fibrosis registry of Türkiye
Autor: Meltem Akgül Erdal, a další
Vydáno: (2025-02-01)

Effectiveness and Safety of Cystic Fibrosis Transmembrane Conductance Regulator Modulators in Children With Cystic Fibrosis: A Meta-Analysis
Autor: Qiyu Li, a další
Vydáno: (2022-06-01)

Corneal Refractive Surgery Considerations in Patients with Cystic Fibrosis and Cystic Fibrosis Transmembrane Conductance Regulator-Related Disorders
Autor: Moshirfar M, a další
Vydáno: (2022-11-01)

The effect of cystic fibrosis transmembrane conductance regulator modulators on impaired glucose tolerance and cystic fibrosis related diabetes
Autor: Sana Hasan, a další
Vydáno: (2022-09-01)

Cystic Fibrosis Transmembrane Conductance Regulator Genotype, Not Circulating Catecholamines, Influences Cardiovascular Function in Patients with Cystic Fibrosis
Autor: Alexander L Bisch, a další
Vydáno: (2019-03-01)

Cystic fibrosis transmembrane conductance regulator (CFTR) allelic variants relate to shifts in faecal microbiota of cystic fibrosis patients.
Autor: Serena Schippa, a další
Vydáno: (2013-01-01)

Characterisation of the salmon cystic fibrosis transmembrane conductance regulator protein for structural studies
Autor: Naomi L. Pollock, a další
Vydáno: (2014-11-01)

Lack of correlation between pulmonary disease and cystic fibrosis transmembrane conductance regulator dysfunction in cystic fibrosis: a case report
Autor: Cleveland Robert H, a další
Vydáno: (2010-04-01)

Correction: Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Allelic Variants Relate to Shifts in Faecal Microbiota of Cystic Fibrosis Patients
Vydáno: (2013-01-01)

Correction: Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Allelic Variants Relate to Shifts in Faecal Microbiota of Cystic Fibrosis Patients.
Autor: Serena Schippa, a další
Vydáno: (2013-01-01)

Identification and developmental expression of the Xenopus laevis cystic fibrosis transmembrane conductance regulator gene.
Autor: Tucker, S, a další
Vydáno: (1992)

Relating the disease mutation spectrum to the evolution of the cystic fibrosis transmembrane conductance regulator (CFTR).
Autor: Lavanya Rishishwar, a další
Vydáno: (2012-01-01)

The Cystic Fibrosis Transmembrane Regulator (CFTR) in the kidney
Autor: MARCELO M. MORALES, a další
Vydáno: (2000-09-01)

Diagnostic contribution of molecular analysis of the cystic fibrosis transmembrane conductance regulator gene in patients suspected of having mild or atypical cystic fibrosis
Autor: Vinícius Buaes Dal'Maso, a další
Vydáno: (2013-04-01)

Differential thermostability and response to cystic fibrosis transmembrane conductance regulator (CFTR) potentiators of human and mouse F508del-CFTR
Autor: Bose, S, a další
Vydáno: (2019)

Cystic Fibrosis: Understanding Cystic Fibrosis Transmembrane Regulator Mutation Classification and Modulator Therapies
Autor: Saba Anwar, a další
Vydáno: (2024-07-01)

Allergic Bronchopulmonary Aspergillosis (ABPA) in the Era of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators
Autor: Paulami Chatterjee, a další
Vydáno: (2024-09-01)

Cystic Fibrosis Transmembrane Conductance Regulator Gene Abnormalities in Patients with Asthma and Recurrent Neutrophilic Bronchitis
Autor: Jodi Goodwin, a další
Vydáno: (2012-01-01)

Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
Autor: Stephanie Chin, a další
Vydáno: (2019-07-01)

Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR)
Autor: B. B. Stauffer, a další
Vydáno: (2017-06-01)

A Comparative Analysis of Pricing and Reimbursement of Cystic Fibrosis Transmembrane Conductance Regulator Modulators in Europe
Autor: Khadidja Abdallah, a další
Vydáno: (2021-11-01)

Characterization of the Trafficking Pathway of Cystic Fibrosis Transmembrane Conductance Regulator in Baby Hamster Kidney Cells
Autor: Tsukasa Okiyoneda, a další
Vydáno: (2004-01-01)

Human amnion epithelial cells induced to express functional cystic fibrosis transmembrane conductance regulator.
Autor: Sean V Murphy, a další
Vydáno: (2012-01-01)

Benign and Deleterious Cystic Fibrosis Transmembrane Conductance Regulator Mutations Identified by Sequencing in Positive Cystic Fibrosis Newborn Screen Children from California.
Autor: Danieli B Salinas, a další
Vydáno: (2016-01-01)