p97/VCP- and Lys48-linked polyubiquitination form a new signaling pathway in DNA damage response.
RNF8/RNF168-dependent Lys63-linked polyubiquitination at sites of DNA double-strand breaks (DSBs) was originally regarded as the sole ubiquitin-signaling pathway involved in the DNA damage response (DDR). However, ubiquitin-dependent p97/VCP segregase activity and RNF8-dependent Lys48-linked polyubi...
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
2012
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