Neuronal oscillations on evolving networks: dynamics, damage, degradation, decline, dementia, and death
Neurodegenerative diseases, such as Alzheimer’s or Parkinson’s disease, show characteristic degradation of structural brain networks. This degradation eventually leads to changes in the network dynamics and degradation of cognitive functions. Here, we model the progression in terms of coupled physic...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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American Physical Society
2020
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| _version_ | 1797107502063550464 |
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| author | Goriely, A Kuhl, E Bick, C |
| author_facet | Goriely, A Kuhl, E Bick, C |
| author_sort | Goriely, A |
| collection | OXFORD |
| description | Neurodegenerative diseases, such as Alzheimer’s or Parkinson’s disease, show characteristic degradation of structural brain networks. This degradation eventually leads to changes in the network dynamics and degradation of cognitive functions. Here, we model the progression in terms of coupled physical processes: The accumulation of toxic proteins, given by a nonlinear reaction-diffusion transport process, yields an evolving brain connectome characterized by weighted edges on which a neuronal-mass model evolves. The progression of the brain functions can be tested by simulating the resting-state activity on the evolving brain network. We show that while the evolution of edge weights plays a minor role in the overall progression of the disease, dynamic biomarkers predict a transition over a period of 10 years associated with strong cognitive decline. |
| first_indexed | 2024-03-07T07:15:34Z |
| format | Journal article |
| id | oxford-uuid:949d643c-3f8a-43c7-80bb-f7dbc4275eab |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:15:34Z |
| publishDate | 2020 |
| publisher | American Physical Society |
| record_format | dspace |
| spelling | oxford-uuid:949d643c-3f8a-43c7-80bb-f7dbc4275eab2022-08-10T11:19:50ZNeuronal oscillations on evolving networks: dynamics, damage, degradation, decline, dementia, and deathJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:949d643c-3f8a-43c7-80bb-f7dbc4275eabEnglishSymplectic ElementsAmerican Physical Society2020Goriely, AKuhl, EBick, CNeurodegenerative diseases, such as Alzheimer’s or Parkinson’s disease, show characteristic degradation of structural brain networks. This degradation eventually leads to changes in the network dynamics and degradation of cognitive functions. Here, we model the progression in terms of coupled physical processes: The accumulation of toxic proteins, given by a nonlinear reaction-diffusion transport process, yields an evolving brain connectome characterized by weighted edges on which a neuronal-mass model evolves. The progression of the brain functions can be tested by simulating the resting-state activity on the evolving brain network. We show that while the evolution of edge weights plays a minor role in the overall progression of the disease, dynamic biomarkers predict a transition over a period of 10 years associated with strong cognitive decline. |
| spellingShingle | Goriely, A Kuhl, E Bick, C Neuronal oscillations on evolving networks: dynamics, damage, degradation, decline, dementia, and death |
| title | Neuronal oscillations on evolving networks: dynamics, damage, degradation, decline, dementia, and death |
| title_full | Neuronal oscillations on evolving networks: dynamics, damage, degradation, decline, dementia, and death |
| title_fullStr | Neuronal oscillations on evolving networks: dynamics, damage, degradation, decline, dementia, and death |
| title_full_unstemmed | Neuronal oscillations on evolving networks: dynamics, damage, degradation, decline, dementia, and death |
| title_short | Neuronal oscillations on evolving networks: dynamics, damage, degradation, decline, dementia, and death |
| title_sort | neuronal oscillations on evolving networks dynamics damage degradation decline dementia and death |
| work_keys_str_mv | AT gorielya neuronaloscillationsonevolvingnetworksdynamicsdamagedegradationdeclinedementiaanddeath AT kuhle neuronaloscillationsonevolvingnetworksdynamicsdamagedegradationdeclinedementiaanddeath AT bickc neuronaloscillationsonevolvingnetworksdynamicsdamagedegradationdeclinedementiaanddeath |