Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol, a DT-diaphorase inhibitor.
The purpose of this study was to evaluate the contribution of DT-diaphorase inhibition to in vivo neurodegenerative effects of dopamine (DA) oxidation to the corresponding o-quinones. The neurotoxicity to nigrostriatal DA neurons was induced by injection of manganese pyrophosphate (Mn(3+)) complex a...
Auteurs principaux: | Díaz-Véliz, G, Mora, S, Gómez, P, Dossi, M, Montiel, J, Arriagada, C, Aboitiz, F, Segura-Aguilar, J |
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Format: | Journal article |
Langue: | English |
Publié: |
2004
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