Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol, a DT-diaphorase inhibitor.

Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol, a DT-diaphorase inhibitor.

The purpose of this study was to evaluate the contribution of DT-diaphorase inhibition to in vivo neurodegenerative effects of dopamine (DA) oxidation to the corresponding o-quinones. The neurotoxicity to nigrostriatal DA neurons was induced by injection of manganese pyrophosphate (Mn(3+)) complex a...

书目详细资料
Main Authors:	Díaz-Véliz, G, Mora, S, Gómez, P, Dossi, M, Montiel, J, Arriagada, C, Aboitiz, F, Segura-Aguilar, J
格式:	Journal article
语言:	English
出版:	2004

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