Babies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study.
OBJECTIVES: Pre-eclampsia (PE) is associated with an increased incidence of cardiovascular disease in later life. Daughters of PE mothers have an increased risk of developing the disease; recent epidemiological data suggest a (grand)paternal contribution. We have directly studied the parents of 673...
| Main Author: | |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1797082924920602624 |
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| author | Genetics of Pre-eclampsia (GOPEC) consortium |
| author_facet | Genetics of Pre-eclampsia (GOPEC) consortium |
| author_sort | Genetics of Pre-eclampsia (GOPEC) consortium |
| collection | OXFORD |
| description | OBJECTIVES: Pre-eclampsia (PE) is associated with an increased incidence of cardiovascular disease in later life. Daughters of PE mothers have an increased risk of developing the disease; recent epidemiological data suggest a (grand)paternal contribution. We have directly studied the parents of 673 women with stringently defined PE in relation to their daughters' disease. METHODS: (Grand)parental medical history, current medication and blood pressure (using an Omron 705 automated monitor) were recorded, with obstetric history for the grandmother, including directly verified pregnancy hypertension. RESULTS: The age of the 649 participating grandmothers was 55.5 +/- 7.5 years (mean +/- SD) and that of the 542 participating grandfathers was 58.0 +/- 7.3 years. Essential hypertension (EHT) requiring therapy was present in 23.4% of the grandmothers and 22.8% of the grandfathers. Patients had moderate to severe PE; a quarter were delivered before 34 weeks' gestation. A third of the babies had birthweights below the third centile; the perinatal mortality rate was 2.1%. Grandparental absolute systolic pressures and EHT status were highly significant determinants of maternal systolic pressure during gestation (F = 11.8, P < 0.001; F = 8.91, P = 0.003, respectively); maternal body mass index (BMI) had less effect. A similar, less marked, pattern was seen for diastolic pressure (F = 6.01, P = 0.014; F = 11.50, P < 0.0001). Grandmaternal EHT did not influence her daughter's systolic or diastolic pressure (P > 0.2 for both). CONCLUSIONS: A paternal, but not maternal, history of EHT is associated with increased risks of non-pregnant hypertension in the children, the risk being greater in daughters than sons. Pregnancy may unveil or exacerbate this effect, possibly reflecting underlying endothelial vulnerability. |
| first_indexed | 2024-03-07T01:34:49Z |
| format | Journal article |
| id | oxford-uuid:94c7f9af-4db8-4e18-a803-ac3d0923f9b4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:34:49Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:94c7f9af-4db8-4e18-a803-ac3d0923f9b42022-03-26T23:41:53ZBabies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:94c7f9af-4db8-4e18-a803-ac3d0923f9b4EnglishSymplectic Elements at Oxford2007Genetics of Pre-eclampsia (GOPEC) consortium OBJECTIVES: Pre-eclampsia (PE) is associated with an increased incidence of cardiovascular disease in later life. Daughters of PE mothers have an increased risk of developing the disease; recent epidemiological data suggest a (grand)paternal contribution. We have directly studied the parents of 673 women with stringently defined PE in relation to their daughters' disease. METHODS: (Grand)parental medical history, current medication and blood pressure (using an Omron 705 automated monitor) were recorded, with obstetric history for the grandmother, including directly verified pregnancy hypertension. RESULTS: The age of the 649 participating grandmothers was 55.5 +/- 7.5 years (mean +/- SD) and that of the 542 participating grandfathers was 58.0 +/- 7.3 years. Essential hypertension (EHT) requiring therapy was present in 23.4% of the grandmothers and 22.8% of the grandfathers. Patients had moderate to severe PE; a quarter were delivered before 34 weeks' gestation. A third of the babies had birthweights below the third centile; the perinatal mortality rate was 2.1%. Grandparental absolute systolic pressures and EHT status were highly significant determinants of maternal systolic pressure during gestation (F = 11.8, P < 0.001; F = 8.91, P = 0.003, respectively); maternal body mass index (BMI) had less effect. A similar, less marked, pattern was seen for diastolic pressure (F = 6.01, P = 0.014; F = 11.50, P < 0.0001). Grandmaternal EHT did not influence her daughter's systolic or diastolic pressure (P > 0.2 for both). CONCLUSIONS: A paternal, but not maternal, history of EHT is associated with increased risks of non-pregnant hypertension in the children, the risk being greater in daughters than sons. Pregnancy may unveil or exacerbate this effect, possibly reflecting underlying endothelial vulnerability. |
| spellingShingle | Genetics of Pre-eclampsia (GOPEC) consortium Babies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study. |
| title | Babies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study. |
| title_full | Babies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study. |
| title_fullStr | Babies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study. |
| title_full_unstemmed | Babies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study. |
| title_short | Babies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study. |
| title_sort | babies pre eclamptic mothers and grandparents a three generation phenotyping study |
| work_keys_str_mv | AT geneticsofpreeclampsiagopecconsortium babiespreeclampticmothersandgrandparentsathreegenerationphenotypingstudy |