Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer’s disease
<p>To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and glucose to active neurons. Rather than relying on metabolic feedback signals such as the consumption of oxyg...
| Päätekijät: | , , , , |
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
Oxford University Press
2022
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| _version_ | 1826310418000248832 |
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| author | Zhu, WM Neuhaus, A Beard, DJ Sutherland, BA DeLuca, GC |
| author_facet | Zhu, WM Neuhaus, A Beard, DJ Sutherland, BA DeLuca, GC |
| author_sort | Zhu, WM |
| collection | OXFORD |
| description | <p>To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and glucose to active neurons. Rather than relying on metabolic feedback signals such as the consumption of oxygen or glucose, the main signalling pathways rely on the release of vasoactive molecules by neurons and astrocytes, which act on contractile cells. Vascular smooth muscle cells and pericytes are the contractile cells associated with arterioles and capillaries, respectively, which relax and induce vasodilation.</p><br>
<p>Much progress has been made in understanding the complex signalling pathways of neurovascular coupling, but issues such as the contributions of capillary pericytes and astrocyte calcium signal remain contentious. Study of neurovascular coupling mechanisms is especially important as cerebral blood flow dysregulation is a prominent feature of Alzheimer’s disease. In this article we will discuss developments and controversies in the understanding of neurovascular coupling and finish by discussing current knowledge concerning neurovascular uncoupling in Alzheimer’s disease.</p> |
| first_indexed | 2024-03-07T07:51:10Z |
| format | Journal article |
| id | oxford-uuid:94e5b7fe-7f29-4ea5-8fd5-5e8111899172 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:51:10Z |
| publishDate | 2022 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:94e5b7fe-7f29-4ea5-8fd5-5e81118991722023-07-12T16:29:03ZNeurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer’s diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:94e5b7fe-7f29-4ea5-8fd5-5e8111899172EnglishSymplectic ElementsOxford University Press2022Zhu, WMNeuhaus, ABeard, DJSutherland, BADeLuca, GC<p>To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and glucose to active neurons. Rather than relying on metabolic feedback signals such as the consumption of oxygen or glucose, the main signalling pathways rely on the release of vasoactive molecules by neurons and astrocytes, which act on contractile cells. Vascular smooth muscle cells and pericytes are the contractile cells associated with arterioles and capillaries, respectively, which relax and induce vasodilation.</p><br> <p>Much progress has been made in understanding the complex signalling pathways of neurovascular coupling, but issues such as the contributions of capillary pericytes and astrocyte calcium signal remain contentious. Study of neurovascular coupling mechanisms is especially important as cerebral blood flow dysregulation is a prominent feature of Alzheimer’s disease. In this article we will discuss developments and controversies in the understanding of neurovascular coupling and finish by discussing current knowledge concerning neurovascular uncoupling in Alzheimer’s disease.</p> |
| spellingShingle | Zhu, WM Neuhaus, A Beard, DJ Sutherland, BA DeLuca, GC Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer’s disease |
| title | Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer’s disease |
| title_full | Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer’s disease |
| title_fullStr | Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer’s disease |
| title_full_unstemmed | Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer’s disease |
| title_short | Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer’s disease |
| title_sort | neurovascular coupling mechanisms in health and neurovascular uncoupling in alzheimer s disease |
| work_keys_str_mv | AT zhuwm neurovascularcouplingmechanismsinhealthandneurovascularuncouplinginalzheimersdisease AT neuhausa neurovascularcouplingmechanismsinhealthandneurovascularuncouplinginalzheimersdisease AT bearddj neurovascularcouplingmechanismsinhealthandneurovascularuncouplinginalzheimersdisease AT sutherlandba neurovascularcouplingmechanismsinhealthandneurovascularuncouplinginalzheimersdisease AT delucagc neurovascularcouplingmechanismsinhealthandneurovascularuncouplinginalzheimersdisease |