Identification of loci associated with schizophrenia by genome-wide association and follow-up
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 × 10-4), and the overall pattern of replication was unlikely to...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1826285869687898112 |
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| author | O'Donovan, M Craddock, N Norton, N Williams, H Peirce, T Moskvina, V Nikolov, I Hamshere, M Carroll, L Georgieva, L Dwyer, S Holmans, P Marchini, J Spencer, C Howie, B Leung, H Hartmann, A Möller, H Morris, D Shi, Y Feng, G Hoffmann, P Propping, P Vasilescu, C Maier, W |
| author_facet | O'Donovan, M Craddock, N Norton, N Williams, H Peirce, T Moskvina, V Nikolov, I Hamshere, M Carroll, L Georgieva, L Dwyer, S Holmans, P Marchini, J Spencer, C Howie, B Leung, H Hartmann, A Möller, H Morris, D Shi, Y Feng, G Hoffmann, P Propping, P Vasilescu, C Maier, W |
| author_sort | O'Donovan, M |
| collection | OXFORD |
| description | We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 × 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10-9). © 2008 Nature Publishing Group. |
| first_indexed | 2024-03-07T01:35:18Z |
| format | Journal article |
| id | oxford-uuid:94f6ad9c-482b-4d28-b8a1-367ef45c7188 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:35:18Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:94f6ad9c-482b-4d28-b8a1-367ef45c71882022-03-26T23:43:03ZIdentification of loci associated with schizophrenia by genome-wide association and follow-upJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:94f6ad9c-482b-4d28-b8a1-367ef45c7188EnglishSymplectic Elements at Oxford2008O'Donovan, MCraddock, NNorton, NWilliams, HPeirce, TMoskvina, VNikolov, IHamshere, MCarroll, LGeorgieva, LDwyer, SHolmans, PMarchini, JSpencer, CHowie, BLeung, HHartmann, AMöller, HMorris, DShi, YFeng, GHoffmann, PPropping, PVasilescu, CMaier, WWe carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 × 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10-9). © 2008 Nature Publishing Group. |
| spellingShingle | O'Donovan, M Craddock, N Norton, N Williams, H Peirce, T Moskvina, V Nikolov, I Hamshere, M Carroll, L Georgieva, L Dwyer, S Holmans, P Marchini, J Spencer, C Howie, B Leung, H Hartmann, A Möller, H Morris, D Shi, Y Feng, G Hoffmann, P Propping, P Vasilescu, C Maier, W Identification of loci associated with schizophrenia by genome-wide association and follow-up |
| title | Identification of loci associated with schizophrenia by genome-wide association and follow-up |
| title_full | Identification of loci associated with schizophrenia by genome-wide association and follow-up |
| title_fullStr | Identification of loci associated with schizophrenia by genome-wide association and follow-up |
| title_full_unstemmed | Identification of loci associated with schizophrenia by genome-wide association and follow-up |
| title_short | Identification of loci associated with schizophrenia by genome-wide association and follow-up |
| title_sort | identification of loci associated with schizophrenia by genome wide association and follow up |
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