The major histocompatibility complex, mate choice and pathogen resistance in the European badger Meles meles
<p>Studies of the evolution of the major histocompatibility complex (MHC) have been central to the understanding sexual selection and pathogen-mediated selection. The European badger <em>Meles meles</em> is well suited for exploring such questions because of its life history charac...
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| Format: | Thesis |
| Language: | English |
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2014
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| _version_ | 1797082979356377088 |
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| author | Sin, Y |
| author2 | Macdonald, D |
| author_facet | Macdonald, D Sin, Y |
| author_sort | Sin, Y |
| collection | OXFORD |
| description | <p>Studies of the evolution of the major histocompatibility complex (MHC) have been central to the understanding sexual selection and pathogen-mediated selection. The European badger <em>Meles meles</em> is well suited for exploring such questions because of its life history characteristics, reproductive biology and mating system. In this thesis, I examined both MHC class I and class II genes. Seven putatively functional sequences were found for class I genes and four for class II DRB genes. Evidence of past balancing selection of both genes was demonstrated by the <em>d</em><sub>N</sub><em>d</em><sub>S</sub> ratio, by positive selection at the antigen-binding site (ABS) and by trans-species polymorphism of alleles within other mustelids and carnivores. MHC class I genes also showed evidence of concerted evolution, but domains showed different evolutionary histories. MHC genes may influence microbiota and odour of an individual and influence mating preferences. I examined the bacterial community of the subcaudal gland secretion and demonstrated a high number of bacterial species (56 operational taxonomic units), which cubs exhibited a higher diversity than adults. The microbiota may lead to an individual-specific odour as a cue signaling the MHC genotype of potential mating partners. I report the first evidence for a MHC- based mating preference in carnivores. Female badgers showed a MHC-assortative mate choice towards breeding with males that had functionally similar MHC genes, for MHC class II DRB genes. This applied to neighbouring-group matings. I also found considerable annual fluctuation in the occurrence of MHC-based mate choice. Based on genome-wide background in the same mating randomizations I found no evidence of inbreeding, which indicated that MHC similarity was apparently the actual target of mate choice. In line with MHC-assortative mate choice, MHC heterozygosity had no influence on the co-infection status. Individual MHC alleles did, however, associate with resistance and susceptibility to specific pathogens, suggesting that MHC diversity may be driven and maintained by pathogen-mediated selection through rare-allele advantages and/or fluctuating selection. My study of genetic characteristics, mate choice and pathogen pressures in a wild population revealed past and contemporary evolutionary process of the MHC genes. This increases knowledge of how the MHC may affect mating behaviour and sexual selection, ultimately influencing population processes.</p> |
| first_indexed | 2024-03-07T01:35:36Z |
| format | Thesis |
| id | oxford-uuid:951310f6-63d8-4fbc-893a-dcd319e1a1d9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:35:36Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:951310f6-63d8-4fbc-893a-dcd319e1a1d92022-03-26T23:43:40ZThe major histocompatibility complex, mate choice and pathogen resistance in the European badger Meles melesThesishttp://purl.org/coar/resource_type/c_db06uuid:951310f6-63d8-4fbc-893a-dcd319e1a1d9Zoological sciencesEcology (zoology)Disease (zoology)ParasitologyBehaviour (zoology)Evolution (zoology)Genetics (life sciences)BiologyEnglishOxford University Research Archive - Valet2014Sin, YMacdonald, D<p>Studies of the evolution of the major histocompatibility complex (MHC) have been central to the understanding sexual selection and pathogen-mediated selection. The European badger <em>Meles meles</em> is well suited for exploring such questions because of its life history characteristics, reproductive biology and mating system. In this thesis, I examined both MHC class I and class II genes. Seven putatively functional sequences were found for class I genes and four for class II DRB genes. Evidence of past balancing selection of both genes was demonstrated by the <em>d</em><sub>N</sub><em>d</em><sub>S</sub> ratio, by positive selection at the antigen-binding site (ABS) and by trans-species polymorphism of alleles within other mustelids and carnivores. MHC class I genes also showed evidence of concerted evolution, but domains showed different evolutionary histories. MHC genes may influence microbiota and odour of an individual and influence mating preferences. I examined the bacterial community of the subcaudal gland secretion and demonstrated a high number of bacterial species (56 operational taxonomic units), which cubs exhibited a higher diversity than adults. The microbiota may lead to an individual-specific odour as a cue signaling the MHC genotype of potential mating partners. I report the first evidence for a MHC- based mating preference in carnivores. Female badgers showed a MHC-assortative mate choice towards breeding with males that had functionally similar MHC genes, for MHC class II DRB genes. This applied to neighbouring-group matings. I also found considerable annual fluctuation in the occurrence of MHC-based mate choice. Based on genome-wide background in the same mating randomizations I found no evidence of inbreeding, which indicated that MHC similarity was apparently the actual target of mate choice. In line with MHC-assortative mate choice, MHC heterozygosity had no influence on the co-infection status. Individual MHC alleles did, however, associate with resistance and susceptibility to specific pathogens, suggesting that MHC diversity may be driven and maintained by pathogen-mediated selection through rare-allele advantages and/or fluctuating selection. My study of genetic characteristics, mate choice and pathogen pressures in a wild population revealed past and contemporary evolutionary process of the MHC genes. This increases knowledge of how the MHC may affect mating behaviour and sexual selection, ultimately influencing population processes.</p> |
| spellingShingle | Zoological sciences Ecology (zoology) Disease (zoology) Parasitology Behaviour (zoology) Evolution (zoology) Genetics (life sciences) Biology Sin, Y The major histocompatibility complex, mate choice and pathogen resistance in the European badger Meles meles |
| title | The major histocompatibility complex, mate choice and pathogen resistance in the European badger Meles meles |
| title_full | The major histocompatibility complex, mate choice and pathogen resistance in the European badger Meles meles |
| title_fullStr | The major histocompatibility complex, mate choice and pathogen resistance in the European badger Meles meles |
| title_full_unstemmed | The major histocompatibility complex, mate choice and pathogen resistance in the European badger Meles meles |
| title_short | The major histocompatibility complex, mate choice and pathogen resistance in the European badger Meles meles |
| title_sort | major histocompatibility complex mate choice and pathogen resistance in the european badger meles meles |
| topic | Zoological sciences Ecology (zoology) Disease (zoology) Parasitology Behaviour (zoology) Evolution (zoology) Genetics (life sciences) Biology |
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