Sex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in men
<p style="text-align:justify;"> <b>Context and Objective:</b> In most populations a greater proportion of men have hepatic steatosis than women. Sex-specific differences in hepatic dietary fatty acid (FA) metabolism have not been well characterized. We compared fasting a...
| Главные авторы: | , , , , , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
Endocrine Society
2015
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| _version_ | 1826285904749133824 |
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| author | Pramfalk, C Pavlides, M Banerjee, R McNeil, C Neubauer, S Karpe, F Hodson, L |
| author_facet | Pramfalk, C Pavlides, M Banerjee, R McNeil, C Neubauer, S Karpe, F Hodson, L |
| author_sort | Pramfalk, C |
| collection | OXFORD |
| description | <p style="text-align:justify;"> <b>Context and Objective:</b> In most populations a greater proportion of men have hepatic steatosis than women. Sex-specific differences in hepatic dietary fatty acid (FA) metabolism have not been well characterized. We compared fasting and postprandial hepatic FA synthesis (de novo lipogenesis [DNL]) and oxidation in men and women.<br/> <b>Participants and Methods:</b> Fasting and postprandial hepatic FA metabolism was studied in 22 healthy men (n = 11) and women with similar age, body mass index, and liver fat content using metabolic substrates labeled with stable-isotope tracers (2H2O and [U13C]palmitate). Dietary FA oxidation was assessed by appearance of 13C into plasma 3-hydroxybutyrate and breath CO2 as markers of liver and whole-body FA oxidation, respectively.<br/> <b>Results:</b> Despite similar liver fat content, fasting and postprandial plasma triacylglycerol (TG) concentrations were significantly (P < .05) higher in men compared with women. The appearance of 13C from dietary FA into plasma 3-hydroxybutyrate and breath CO2 was greater (P < .05) in women compared with men. Although the contribution of DNL into very low-density lipoprotein (VLDL)-TG was similar (∼10%) in the fasting state, there was a divergence in pattern over the course of the study, with men maintaining a higher contribution of DNL to VLDL-TG than women (P = .006 time x sex interaction).<br/> <b>Conclusions:</b> The combination of lower dietary FA oxidation and a prolonged increase in DNL observed in men may represent partitioning of FA into esterification and storage pathways within the liver, leading to greater VLDL-TG production, and predispose to the sex difference in hepatic steatosis.</p> |
| first_indexed | 2024-03-07T01:35:49Z |
| format | Journal article |
| id | oxford-uuid:95266c0c-557f-4352-b181-010342c995ce |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:35:49Z |
| publishDate | 2015 |
| publisher | Endocrine Society |
| record_format | dspace |
| spelling | oxford-uuid:95266c0c-557f-4352-b181-010342c995ce2022-03-26T23:44:13ZSex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in menJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:95266c0c-557f-4352-b181-010342c995ceEnglishSymplectic Elements at OxfordEndocrine Society2015Pramfalk, CPavlides, MBanerjee, RMcNeil, CNeubauer, SKarpe, FHodson, L <p style="text-align:justify;"> <b>Context and Objective:</b> In most populations a greater proportion of men have hepatic steatosis than women. Sex-specific differences in hepatic dietary fatty acid (FA) metabolism have not been well characterized. We compared fasting and postprandial hepatic FA synthesis (de novo lipogenesis [DNL]) and oxidation in men and women.<br/> <b>Participants and Methods:</b> Fasting and postprandial hepatic FA metabolism was studied in 22 healthy men (n = 11) and women with similar age, body mass index, and liver fat content using metabolic substrates labeled with stable-isotope tracers (2H2O and [U13C]palmitate). Dietary FA oxidation was assessed by appearance of 13C into plasma 3-hydroxybutyrate and breath CO2 as markers of liver and whole-body FA oxidation, respectively.<br/> <b>Results:</b> Despite similar liver fat content, fasting and postprandial plasma triacylglycerol (TG) concentrations were significantly (P < .05) higher in men compared with women. The appearance of 13C from dietary FA into plasma 3-hydroxybutyrate and breath CO2 was greater (P < .05) in women compared with men. Although the contribution of DNL into very low-density lipoprotein (VLDL)-TG was similar (∼10%) in the fasting state, there was a divergence in pattern over the course of the study, with men maintaining a higher contribution of DNL to VLDL-TG than women (P = .006 time x sex interaction).<br/> <b>Conclusions:</b> The combination of lower dietary FA oxidation and a prolonged increase in DNL observed in men may represent partitioning of FA into esterification and storage pathways within the liver, leading to greater VLDL-TG production, and predispose to the sex difference in hepatic steatosis.</p> |
| spellingShingle | Pramfalk, C Pavlides, M Banerjee, R McNeil, C Neubauer, S Karpe, F Hodson, L Sex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in men |
| title | Sex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in men |
| title_full | Sex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in men |
| title_fullStr | Sex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in men |
| title_full_unstemmed | Sex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in men |
| title_short | Sex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in men |
| title_sort | sex specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for nafld in men |
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